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DNA Nanodevices as Mechanical Probes of Protein Structure and Function

1
School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA
2
Biodesign Center for Molecular Design and Biomimetics, Arizona State University, Tempe, AZ 85281, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander E. Marras
Appl. Sci. 2021, 11(6), 2802; https://doi.org/10.3390/app11062802
Received: 13 February 2021 / Revised: 10 March 2021 / Accepted: 13 March 2021 / Published: 21 March 2021
(This article belongs to the Special Issue Mechanical Design in DNA Nanotechnology)
DNA nanotechnology has reported a wide range of structurally tunable scaffolds with precise control over their size, shape and mechanical properties. One promising application of these nanodevices is as probes for protein function or determination of protein structure. In this perspective we cover several recent examples in this field, including determining the effect of ligand spacing and multivalency on cell activation, applying forces at the nanoscale, and helping to solve protein structure by cryo-EM. We also highlight some future directions in the chemistry necessary for integrating proteins with DNA nanoscaffolds, as well as opportunities for computational modeling of hybrid protein-DNA nanomaterials. View Full-Text
Keywords: DNA nanotechnology; protein-DNA biomaterials; mechanical nanodevices DNA nanotechnology; protein-DNA biomaterials; mechanical nanodevices
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MDPI and ACS Style

Stephanopoulos, N.; Šulc, P. DNA Nanodevices as Mechanical Probes of Protein Structure and Function. Appl. Sci. 2021, 11, 2802. https://doi.org/10.3390/app11062802

AMA Style

Stephanopoulos N, Šulc P. DNA Nanodevices as Mechanical Probes of Protein Structure and Function. Applied Sciences. 2021; 11(6):2802. https://doi.org/10.3390/app11062802

Chicago/Turabian Style

Stephanopoulos, Nicholas; Šulc, Petr. 2021. "DNA Nanodevices as Mechanical Probes of Protein Structure and Function" Appl. Sci. 11, no. 6: 2802. https://doi.org/10.3390/app11062802

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