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Review

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

1
Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, India
2
Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China
3
Center of Nanofibers and Nanotechnology, National University of Singapore, Singapore 117581, Singapore
*
Authors to whom correspondence should be addressed.
Both authors contributed equally.
Academic Editor: Suwan N. Jayasinghe
Appl. Sci. 2021, 11(23), 11369; https://doi.org/10.3390/app112311369
Received: 11 August 2021 / Revised: 29 September 2021 / Accepted: 16 October 2021 / Published: 1 December 2021
(This article belongs to the Special Issue Selected Papers from MMSE 2021)
The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering. View Full-Text
Keywords: drug delivery systems (DDS); tissue engineering (TE); polymers; collagen; nanoparticle (NP) drug delivery systems (DDS); tissue engineering (TE); polymers; collagen; nanoparticle (NP)
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MDPI and ACS Style

Arun, A.; Malrautu, P.; Laha, A.; Luo, H.; Ramakrishna, S. Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering. Appl. Sci. 2021, 11, 11369. https://doi.org/10.3390/app112311369

AMA Style

Arun A, Malrautu P, Laha A, Luo H, Ramakrishna S. Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering. Applied Sciences. 2021; 11(23):11369. https://doi.org/10.3390/app112311369

Chicago/Turabian Style

Arun, Ashni, Pratyusha Malrautu, Anindita Laha, Hongrong Luo, and Seeram Ramakrishna. 2021. "Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering" Applied Sciences 11, no. 23: 11369. https://doi.org/10.3390/app112311369

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