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Review

Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

1
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo ku, Kumamoto 862-0973, Japan
2
School of Life Sciences, University of Technology Sydney, Sydney, NSW 2007, Australia
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Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia
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Department of Chemistry, Iswar Chandra Vidyasagar College, Belonia 799155, Tripura, India
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Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago 9170022, Chile
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TIFAC-CORE in Herbal Drugs, Department of Pharmacognosy and Phytopharmacy, JSS College of Pharmacy (JSS Academy of Higher Education and Research), Ooty 643001, Tamil Nadu, India
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Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida 201310, Uttar Pradesh, India
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School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India
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Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
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Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia
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Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Sydney, NSW 2007, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Ana M. L. Seca
Appl. Sci. 2021, 11(21), 10205; https://doi.org/10.3390/app112110205
Received: 14 August 2021 / Revised: 22 October 2021 / Accepted: 25 October 2021 / Published: 31 October 2021
The genus Zingiber consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, Zingiber montanum (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medicines and food. The aim of this review was to collect and critically analyze the scientific information about the bioactive compounds and pharmacological activities of Z. montanum with focus on one of the main components, zerumbone (ZER). Various studies have reported the analysis of volatile constituents of the essential oils from Z. montanum. Similarly, many phenylbutanoids, flavonoids and terpenes were also isolated from rhizomes. These essential oils, extracts and compounds showed potent antimicrobial, anti-inflammatory and antioxidant activities among others. Zerumbone has been studied widely for its anticancer, anti-inflammatory, and other pharmacological activities. Future studies should focus on the exploration of various pharmacological activities of other compounds including phenylbutanoids and flavonoids. Bioassay guided isolation may result in the separation of other active components from the extracts. Z. montanum could be a promising source for the development of pharmaceutical products and functional foods. View Full-Text
Keywords: Zingiber montanum; Zingiber cassumunar; zerumbone; anticancer; anti-inflammatory Zingiber montanum; Zingiber cassumunar; zerumbone; anticancer; anti-inflammatory
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MDPI and ACS Style

Devkota, H.P.; Paudel, K.R.; Hassan, M.M.; Dirar, A.I.; Das, N.; Adhikari-Devkota, A.; Echeverría, J.; Logesh, R.; Jha, N.K.; Singh, S.K.; Hansbro, P.M.; Chan, Y.; Chellappan, D.K.; Dua, K. Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone. Appl. Sci. 2021, 11, 10205. https://doi.org/10.3390/app112110205

AMA Style

Devkota HP, Paudel KR, Hassan MM, Dirar AI, Das N, Adhikari-Devkota A, Echeverría J, Logesh R, Jha NK, Singh SK, Hansbro PM, Chan Y, Chellappan DK, Dua K. Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone. Applied Sciences. 2021; 11(21):10205. https://doi.org/10.3390/app112110205

Chicago/Turabian Style

Devkota, Hari Prasad, Keshav Raj Paudel, Md. Mahadi Hassan, Amina Ibrahim Dirar, Niranjan Das, Anjana Adhikari-Devkota, Javier Echeverría, Rajan Logesh, Niraj Kumar Jha, Sachin Kumar Singh, Philip M. Hansbro, Yinghan Chan, Dinesh Kumar Chellappan, and Kamal Dua. 2021. "Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone" Applied Sciences 11, no. 21: 10205. https://doi.org/10.3390/app112110205

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