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Article

Computer Assisted Surgery and 3D Printing in Orthopaedic Oncology: A Lesson Learned by Cranio-Maxillo-Facial Surgery

1
IRCCS Istituto Ortopedico Rizzoli, Clinica Ortopedica III, 40136 Bologna, Italy
2
Unit of Orthodontics, Division of Dentistry IRCSS Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy
3
Unit of Orthodontics, School of Dentistry, Vita-Salute San Raffaele University, 20132 Milan, Italy
4
Research Center for Oral Pathology and Implantology, Unit of Dentistry, IRCSS Ospedale San Raffaele, Scientific Institute, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Oleh Andrukhov
Appl. Sci. 2021, 11(18), 8584; https://doi.org/10.3390/app11188584
Received: 2 August 2021 / Revised: 31 August 2021 / Accepted: 8 September 2021 / Published: 15 September 2021

Abstract

Primary bone sarcomas are rare tumors and surgical resection in combination with chemo and radiation therapy is the mainstay of treatment. Some specific anatomical sites still represent a reconstructive challenge due to their complex three-dimensional anatomy. In recent years, patient specific instruments along with 3D printing technology has come to represent innovative techniques in orthopaedic oncology. We retrospectively reviewed 23 patients affected by primary bone sarcoma treated with patient-specific instruments and 3D printing custom made prostheses. At follow up after approximately two years, the infection rate was 26%, mechanical complication rate 13%, and local recurrence rate 13% (with a five-years implant survival rate of 74%). Based on our experience, patient-specific instruments and 3D custom-made prostheses represents a reliable and safe technique for improving the accuracy of resection of primary bone tumour, with a particular use in pelvic surgery ameliorating functional results.
Keywords: computer assisted surgery; 3D printing; bone sarcomas computer assisted surgery; 3D printing; bone sarcomas

1. Introduction

Primary malignant bone tumors are exceptionally rare, accounting for only 0.2% of all neoplasms with an overall annual incidence rate in Europe of 0.8 per 100,000 people. The incidence rates of specific bone sarcomas are age-related and have a bimodal distribution. Their clinical, radiographic, and histological characteristics are well known and there is consensus on their management (surgery, chemotherapy, and radiotherapy alone or in combination each other) according to national and international treatment protocols in referral centers for bone sarcomas and according to each specific histotype. In localized disease, 5-yrs overall survival is 65% for osteosarcoma, 60–75% for Ewing Sarcoma, and 75–80% for chondrosarcomas [1].
The role of surgery is unquestionable in any other type of primary bone sarcoma. Over the past twenty years, improvements in prosthetic designs, materials and surgical techniques have guaranteed an excellent implant survival and functional outcome (particularly for sarcomas affecting the appendicular skeleton). Nevertheless, some specific sites of presentation (the pelvis, spine, scapula, periarticular tumors) still represent a challenge either for safe tumor resection or for acceptable functional reconstruction due to their complex three-dimensional anatomy.
The uptake in the use of computer assisted surgery and 3D printing is in response to these factors in a bid to minimise the incidence of inadequate resection margins and improving patients’ functional outcome.
In recent years, “image based” computer assisted surgery (CAS) has been developed along with 3D printing technology and now provides opportunities for personalizing reconstruction with custom-made prostheses [2,3,4,5] and improving accuracy in bone cutting using patient-specific instruments (PSI) [6].
Orthopaedic surgery and oral and maxillofacial surgery were among the first specialties to adopt this technology [7,8,9,10,11,12,13,14] and the advent of electron beam melting (EBM) rapid prototyping (RP) techniques have improved the process which directly produces a physical object with a defined structure and shape based on virtual/mathematical model data, ensuring personalized and anatomical reconstructions after bone tumour resection. Rapid prototyping was first used in the late 1990s and was developed to apply the precision and functionality of computer assisted design (CAD) to manufacturing [15]. With this technology, a prototype could be quickly produced and accurately represents the engineers draft [16,17]. Furthermore, if changes needed to be made, the engineer could easily digitally work on the draft and print the redesigned part. The EBM is the optimal technology to fabricate metallic components with complex shapes and porous structures and has a pivotal role either in the PSI technology and prosthesis manufacturing.
PSI technology has been used during the last decade in maxillofacial surgery, total knee arthroplasty, hip resurfacing, pedicle screw insertion, pelvic, and long-bones osteotomy. Evaluation tests have shown a high accuracy when compared to standard methods with reduced surgery time [18,19,20,21,22,23,24,25]. A case example is reported in Figure 1.
The aim of this article is to verify the oncological safety of PSI and 3D custom made prostheses in a selected group of patients affected by primary bone sarcomas.

2. Materials and Methods

From August 2013 to April 2020, 23 patients affected by a primary bone tumour of the pelvis or appendicular skeleton were treated at our Institute with 3D printing custom made prosthesis and PSI technique.
All patients underwent biopsy and histological characterization and complete staging before surgery. Patients affected by malignant tumours received multimodality treatment including surgery, radiotherapy and chemotherapy. Surgery was addressed for limb salvage and to achieve “wide” surgical margins.
Tumour area and surrounding anatomical structures were studied with a CT scan with 1mm slices to achieve a representative 3D model, while MRI images were needed for an adequate evaluation of tumour extent within the bone (both medullary and cortically) and in surrounding soft tissues. Patient-specific instruments (PSIs) and implants were designed according to the planned resection strategy.
The fabrication process both for PSIs either for custom implant is in charge of a company which has a specific expertise and industrial workflow for additive manifacturing. Commercial softwares as well as Mimics® (Materialise, Leuven, Belgium) or Invesalius® (freeware) are mostly used for segmentation. PSIs can be molded in nylon or printed in titanium alloy according to the clinical needs and to the know-how of selected companies.
PSIs had bone specific contact surfaces to fit into unique position on the bony structure of the patient based on the shape of the bone acquired by CT scan. PSIs were equipped with flat surfaces and holes to be pinned temporarily on the bone. The final PSI is printed in Nylon or titanium and made sterile for operation.
The virtual custom prosthesis was created defining the better method of fixation according to the part to be reconstructed mirroring the opposite part.
The Ti-6Al-4V implants were fabricated through the deposition of few micron layers of titanium powder melted by electron beams technology (i.e., Electron Beam Melting technique). Implant porosity is widely variable to increase performance and macro-porosity of the body to lighten the implant till micro-porosity at the bone surface contact. These surfaces have pores with an average size of 0.7 millimetres, allowing the host bone to grow directly inside the implant spaces to achieve a stable biological fixation. The prosthesis was provided of tools to allow fixation to the host bone as well as plates or rods, while screws position and lengths were previously planned as well. For articular reconstruction, a polished manufacture or a surface layer (polycaprolactone, PCL or poly-lactic acid, PLA) can be integrated in porous titanium structure.
All analysis was completed using the Statistical Package for Social Science (IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp.).
All subjects gave their informed consent for inclusion before they participated in the study.
The study was conducted under Ethical Approval of our Institute (approval code 0024015/2014) and in accordance with the Declaration of Helsinki, all data were retrieved from medical and radiological records of our hospital.

3. Results

Among the 23 patients, 5 (22%) were female and 18 (78%) were male. The age ranged from 14 to 76 years old (mean 37). A malignant primary bone tumour was diagnosed in 22 cases (96%), while 1 patient suffered a benign tumour (4%). The pelvic ring was affected in 16 cases (70%), whereas in 7 (30%) the appendicular skeleton and extremities were involved. In the group of pelvic ring, the sacro-iliac joint was involved in 3 patients (19%) and the hip in 13 (81%), requiring sacroiliac joint fusion in the first group and total hip replacement in the second group. Extra pelvic joint involvement was present in two ankles (one distal tibia and one astragalus) and in one shoulder (glenoid). Surgical margins were adequately “wide” in 21 cases (91%) and “marginal” in 2 (9%) on the soft tissue component. All patients with pelvic tumour (complex surgical anatomy) reported wide margins on the bone. (Table 1).
At a mean follow up of two years (range zero to six), all patients were alive and implants were evaluable for oncological, mechanical, and infective complications.
Six patients (26%) reported early implant infection (<1 months), four after pelvic, one after femur, and one after tibial reconstruction. All patients underwent early surgical debridement associated with antibiotics administration and only one case (sacro iliac joint prostheses) was removed at seven months due to the persistence of infection.
Three patients (13%) reported implant mechanical complications at a mean follow up of nine months (range 0–19). One patient with astragalus custom made implant developed degenerative arthritis of the ankle and required a new custom-made prosthetic replacement of the distal tibia. One intercalary diaphyseal tibial reconstruction suffered of delayed implant integration and required additional surgery with structural allograft to improve healing process. In one case of sacro iliac joint reconstruction, a S1 root/screw conflict required screw removal.
Three patients (13%) developed local recurrence at a mean follow up of 30 months (range 13–39). All recurrences occurred after pelvic reconstructions and three underwent hindquarter amputation with prostheses removal.
Overall, three (13%) custom prostheses were removed due to complications (2 recurrence and 1 infection) at a mean time of 18 months (range 1–39) and with an implant specific survival of 74% at five years follow up (Figure 2).

4. Discussion

Surgical resection with wide margins is the mainstay of treatment of primary bone sarcomas in a setting of multimodal approach. Modular prostheses still represent the standard of treatment in long bone periarticular reconstructions with complication rates constantly decreasing in modern modular endoprostheses [26]. Prosthetic diaphyseal reconstruction remain a debate with high incidence of failure [27]. Nevertheless, no “off the shelf” implants are available on the market for periarticular reconstruction of complex anatomical site such as hip and shoulder. Bone allograft reconstructions suffer high risk of infection (18–55%) and mechanical failure (9–22%) and their role is constantly decreasing and confined to specific indication [28,29,30].
Rapid prototyping 3D printing and patient specific instruments have been recently described as an emerging alternative technique for “unconventional” reconstructions not effectively supported by prosthetic or bone graft replacement. Liang et al. [31] reported excellent functional results (75.6%) and good osteointegration in 35 pelvic custom-made prosthesis after en-bloc tumour resection. Zhang et al. [32] reported excellent functional outcome (80.3%) after distal radius resection and custom-made prosthetic replacement. Both of the above-mentioned authors used titanium 3D custom made prostheses manufactured with electron beam melting technology. Other studies encourage the use of this technology also in non-oncological conditions [33,34,35,36,37,38]. Our series of 23 patients showed a five years implant specific survival of 64% with low complication rate if considered surgical anatomy and complexity of the patients. Possible advantages in term of management of implant infection emerged from our series, with 75% of pelvic infection healed after surgical debridement associated with antibiotic administration.
Cernat et al. [39] and Gouin [40] reported 100% of safe margins in a series of 4 (pelvic) and 11 bone tumors respectively using PSI confirming the possibility to carefully plan bone osteotomy with safety. In our series of 16 pelvic tumours PSI confirmed reliability in term of oncological resection with 100% adequate (wide) and recurrences not related to PSI. Soft tissues extend of the tumour may also impact on the jig sitting correctly on bony landmarks thereby potentially compromising the resection. Finally, due to the delay between planning and jig manufacture there is a possibility for disease progression and therefore a mismatch between planned resection and tumour margins, resulting in intralesional resections [41,42,43]. Surgeon error is also possible and misplacement of the jigs can again result in intralesional resections.

5. Conclusions

Patient-specific instruments and 3D custom-made prostheses represents an innovation that can improve the accuracy of resection of primary bone tumour with a particular use in pelvic surgery ameliorating functional results.
Although burdened by high technology costs, time consuming preoperative planning, and a steep learning curve, further development will make this technology more friendly with potential development towards robotic surgery.

Author Contributions

Conceptualization, G.B., T.F.; methodology, G.B., T.F.; software, B.S., D.D.; validation, G.B., A.L.; formal analysis, T.F., B.S.; investigation, D.D., B.S.; resources, B.S., D.D.; data curation, B.S., D.D.; writing-original draft preparation, G.B., T.F.; writing-review and editing, T.F., D.D., and A.L.; supervision, A.L. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted under Ethical Approval of our Institute (approval code 0024015/2014) and in accordance with the Declaration of Helsinki, all data were retrieved from medical and radiological records of our hospital.

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Conflicts of Interest

The authors declare no conflict of interest.

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Figure 1. Case #10, Male 36 years, low grade osteosarcoma, 3D-virtual model of (a) low grade osteosarcoma of the left glenoid, (b) PSI cutting guide, (c) custom made prosthesis, (d) pre-operative plain X-ray, (e) surgical specimen and custom-made prostheses, and (f) plain X-ray (three years follow up).
Figure 1. Case #10, Male 36 years, low grade osteosarcoma, 3D-virtual model of (a) low grade osteosarcoma of the left glenoid, (b) PSI cutting guide, (c) custom made prosthesis, (d) pre-operative plain X-ray, (e) surgical specimen and custom-made prostheses, and (f) plain X-ray (three years follow up).
Applsci 11 08584 g001
Figure 2. Custom prostheses specific survival. Five years implant specific survival of 64%.
Figure 2. Custom prostheses specific survival. Five years implant specific survival of 64%.
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Table 1. Demographics, surgical details, complications and follow up of 23 3D/PSI custom implants; * benign tumour ** low-grade malignant tumour.
Table 1. Demographics, surgical details, complications and follow up of 23 3D/PSI custom implants; * benign tumour ** low-grade malignant tumour.
PatientGenderAgeSiteJoint
Involvement
DiagnosisSurgical
Margins
Revision
Surgery (Months)
Implant
Removal (Months)
Patient
Follow Up (Months)
1M48Tibia MyxofibrosarcomaMarginalInfection (1) 14
2M76PelvisHipChondorsarcomaWideInfection (1) 2
3M18PelvisHipEwing SarcomaWideInfection (1) 76
4F23PelvisHipEwing SarcomaWide 69
5F26Femur OsteosarcomaWide 11
6M22Femur Ewing SarcomaWideInfection (1) 33
7F46AstragalusAnkleOsteosarcomaWideArthritis (19) 19
8M56PelvisSacro IliacChondorsarcomaWideInfection (1)Yes39
9F47PelvisHipChondorsarcomaWideRecurrence (39)Yes44
10M40ScapulaShoulderOsteosarcoma **Wide 3
11M26PelvisSacro IliacEwing SarcomaWideScrew (1) 11
12M45Tibia OsteosarcomaWideNon union (9) 18
13M55PelvisHipChondorsarcomaWideInfection (1) 1
14F40PelvisHipOsteoblastoma *WideRecurrence (37)Yes39
15M38TibiaAnkleChondorsarcomaWide 16
16M14PelvisSacro IliacEwing SarcomaWide 55
17M35PelvisHipChondorsarcomaWide 20
18M28PelvisHipOsteosarcomaMarginal 48
19M45PelvisHipChondorsarcomaWide 33
20M26PelvisHipEwing SarcomaWide 66
21M43PelvisHipOsteosarcomaWide 8
22M26PelvisHipGiant Cell TumorWide 28
23M36PelvisHipChondorsarcomaWideRecurrence (14)Yes62
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