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Management of Patients under Treatment with Monoclonal Antibodies and New Biological Therapies

Department of Medicine and Orofacial Surgery, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Francesco Cappello
Appl. Sci. 2021, 11(11), 4865; https://doi.org/10.3390/app11114865
Received: 28 April 2021 / Revised: 21 May 2021 / Accepted: 22 May 2021 / Published: 25 May 2021
(This article belongs to the Topic Human Anatomy and Pathophysiology)
Objective: The aim of this study is to know the biological therapy drugs that are related to adverse events, what dental treatments are associated with the appearance of these events, their severity, and how they are resolved. Study design: Analysis of cases described in the literature on patients undergoing treatment with biological therapies who have developed adverse effects associated with these drugs. Results: Of the 62 articles reviewed, 49 describe 68 cases of MRONJ, most of which appeared in the jaw and received surgical and/or conservative treatment. Conclusions: Biological therapies can potentially develop adverse effects in the oral cavity, so strict monitoring by the dentist is necessary. View Full-Text
Keywords: target therapy; antiangiogenic agent; denosumab; osteonecrosis of the jaw; monoclonal antibody; stomatitis; dental infection; MRONJ target therapy; antiangiogenic agent; denosumab; osteonecrosis of the jaw; monoclonal antibody; stomatitis; dental infection; MRONJ
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MDPI and ACS Style

Amigo-Basilio, M.; Álvarez-González, C.; Cobo-Vázquez, C.; Leco-Berrocal, I.; Sáez-Alcaide, L.M.; Méniz-García, C. Management of Patients under Treatment with Monoclonal Antibodies and New Biological Therapies. Appl. Sci. 2021, 11, 4865. https://doi.org/10.3390/app11114865

AMA Style

Amigo-Basilio M, Álvarez-González C, Cobo-Vázquez C, Leco-Berrocal I, Sáez-Alcaide LM, Méniz-García C. Management of Patients under Treatment with Monoclonal Antibodies and New Biological Therapies. Applied Sciences. 2021; 11(11):4865. https://doi.org/10.3390/app11114865

Chicago/Turabian Style

Amigo-Basilio, Marta, Covadonga Álvarez-González, Carlos Cobo-Vázquez, Isabel Leco-Berrocal, Luis M. Sáez-Alcaide, and Cristina Méniz-García. 2021. "Management of Patients under Treatment with Monoclonal Antibodies and New Biological Therapies" Applied Sciences 11, no. 11: 4865. https://doi.org/10.3390/app11114865

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