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Open AccessFeature PaperArticle

Quinazolin-4(3H)-ones: A Tangible Synthesis Protocol via an Oxidative Olefin Bond Cleavage Using Metal-Catalyst Free Conditions

Department of Chemistry, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia
Appl. Sci. 2020, 10(8), 2815; https://doi.org/10.3390/app10082815
Received: 31 March 2020 / Revised: 13 April 2020 / Accepted: 15 April 2020 / Published: 18 April 2020
(This article belongs to the Special Issue Recent Advancement in Technology-Driven Organic Synthesis)
An efficient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal- and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields. View Full-Text
Keywords: catalysis; metal-free; catalyst-free; quinazolinone; styrene; o-Aminobenzamide; antioxidant; anticancer catalysis; metal-free; catalyst-free; quinazolinone; styrene; o-Aminobenzamide; antioxidant; anticancer
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Sharif, M. Quinazolin-4(3H)-ones: A Tangible Synthesis Protocol via an Oxidative Olefin Bond Cleavage Using Metal-Catalyst Free Conditions. Appl. Sci. 2020, 10, 2815.

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