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Open AccessArticle

HPLC–PDA and LC–MS/MS Analysis for the Simultaneous Quantification of the 14 Marker Components in Sojadodamgangki-Tang

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(8), 2804;
Received: 20 March 2020 / Revised: 15 April 2020 / Accepted: 15 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Biomedical Application of Plant Extracts)
Sojadodamgangki-tang (SDGT) is a traditional Korean medicine consisting of 12 medicinal herbs that has been used in Korea for the treatment of asthma since ancient times. However, the quality control of herbal formulas that contain two or more herbal medicines remains challenging. In this study, 14 marker components were analyzed simultaneously by using high-performance liquid chromatography with photodiode array detection in addition to the use of liquid chromatography–tandem mass spectrometry for quality evaluation of SDGT. The simultaneous determination of the 14 marker components was validated in terms of linearity, recovery, and precision. The established methods can provide useful data for the quality control of SDGT and related herbal formulas. View Full-Text
Keywords: HPLC–PDA; LC–MS/MS; simultaneous quantification; Sojadodamgangki-tang HPLC–PDA; LC–MS/MS; simultaneous quantification; Sojadodamgangki-tang
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Seo, C.-S.; Lee, M.-Y. HPLC–PDA and LC–MS/MS Analysis for the Simultaneous Quantification of the 14 Marker Components in Sojadodamgangki-Tang. Appl. Sci. 2020, 10, 2804.

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