An Improved Biocompatible Probe for Photoacoustic Tumor Imaging Based on the Conjugation of Melanin to Bovine Serum Albumin
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis of Melanin-BSA Conjugates and PheoBSA-FITC Conjugates
2.2. Cell Line and Animal Models
2.3. In Vitro Characterization of Melanin-BSA Conjugates
2.4. Cell Viability Assay
2.5. PheoBSA-FITC In Vivo Biodistribution Test
2.6. In Vivo Photoacoustic Imaging
3. Results and Discussion
3.1. Synthesis and Characterization of Melanin-BSA Conjugates
3.2. PheoBSA Conjugate D In Vivo Biodistribution and Tumor Detection
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Capozza, M.; Stefania, R.; Rosas, L.; Arena, F.; Consolino, L.; Anemone, A.; Cimino, J.; Longo, D.L.; Aime, S. An Improved Biocompatible Probe for Photoacoustic Tumor Imaging Based on the Conjugation of Melanin to Bovine Serum Albumin. Appl. Sci. 2020, 10, 8313. https://doi.org/10.3390/app10238313
Capozza M, Stefania R, Rosas L, Arena F, Consolino L, Anemone A, Cimino J, Longo DL, Aime S. An Improved Biocompatible Probe for Photoacoustic Tumor Imaging Based on the Conjugation of Melanin to Bovine Serum Albumin. Applied Sciences. 2020; 10(23):8313. https://doi.org/10.3390/app10238313
Chicago/Turabian StyleCapozza, Martina, Rachele Stefania, Luisa Rosas, Francesca Arena, Lorena Consolino, Annasofia Anemone, James Cimino, Dario Livio Longo, and Silvio Aime. 2020. "An Improved Biocompatible Probe for Photoacoustic Tumor Imaging Based on the Conjugation of Melanin to Bovine Serum Albumin" Applied Sciences 10, no. 23: 8313. https://doi.org/10.3390/app10238313
APA StyleCapozza, M., Stefania, R., Rosas, L., Arena, F., Consolino, L., Anemone, A., Cimino, J., Longo, D. L., & Aime, S. (2020). An Improved Biocompatible Probe for Photoacoustic Tumor Imaging Based on the Conjugation of Melanin to Bovine Serum Albumin. Applied Sciences, 10(23), 8313. https://doi.org/10.3390/app10238313