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Article

Rapid Sonochemically-Assisted Synthesis of Highly Stable Gold Nanoparticles as Computed Tomography Contrast Agents

1
Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia
2
Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia
3
Department of Radiology and Molecular Imaging, College of Medicine and Health Science, Sultan Qaboos University, PO. Box 35, Al Khod, Muscat 123, Oman
4
Department of Medical Imaging, Faculty of Applied Medical Science, The Hashemite University, Zarqa 13133, Jordan
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(20), 7020; https://doi.org/10.3390/app10207020
Received: 15 August 2020 / Revised: 16 September 2020 / Accepted: 6 October 2020 / Published: 9 October 2020
(This article belongs to the Special Issue Synthesis and Biomedical Application of Nanoparticles)
One of the most widely used modalities of clinical imaging is computed tomography (CT). Recent reports of new contrast agents toward CT imaging have been numerous. The production of gold nanoparticles (AuNPs) as contrast agents for CT is primarily a topic of intense interest. AuNPs have beneficial features for this application, including excellent X-ray attenuation, flexible sizes and shapes, tailorable surface chemistry, excellent biocompatibility and high levels of contrast generating matter. AuNPs with a size of about 18.5 nm and semi-spherical shape were synthesized using a sonochemical method. The attenuation rate of X-rays as measured in Hounsfield units per unit concentration (HU/mg) was measured. Ultrasound treatment for a duration of five min has been shown to produce highly stable AuNPs in different media (AuNPs in water and phosphate-buffered saline (PBS) was −42.1 mV and −39.5 mV, respectively). The CT value (HU = 395) of the AuNPs increased linearly with an increase in the AuNP dosage. The results confirm the use of ultrasonic treatment for the production of metal nanostructures, particularly highly stable non-toxic AuNPs, with good morphology and high-quality crystal structure using an easy and fast method. Synthesized AuNPs have the potential to be used as a CT contrast agent in medical imaging applications. View Full-Text
Keywords: sonochemical method; AuNPs; zeta potential; highly stable sonochemical method; AuNPs; zeta potential; highly stable
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MDPI and ACS Style

Ali Dheyab, M.; Abdul Aziz, A.; Jameel, M.S.; Moradi Khaniabadi, P.; Oglat, A.A. Rapid Sonochemically-Assisted Synthesis of Highly Stable Gold Nanoparticles as Computed Tomography Contrast Agents. Appl. Sci. 2020, 10, 7020. https://doi.org/10.3390/app10207020

AMA Style

Ali Dheyab M, Abdul Aziz A, Jameel MS, Moradi Khaniabadi P, Oglat AA. Rapid Sonochemically-Assisted Synthesis of Highly Stable Gold Nanoparticles as Computed Tomography Contrast Agents. Applied Sciences. 2020; 10(20):7020. https://doi.org/10.3390/app10207020

Chicago/Turabian Style

Ali Dheyab, Mohammed, Azlan Abdul Aziz, Mahmood S. Jameel, Pegah Moradi Khaniabadi, and Ammar A. Oglat. 2020. "Rapid Sonochemically-Assisted Synthesis of Highly Stable Gold Nanoparticles as Computed Tomography Contrast Agents" Applied Sciences 10, no. 20: 7020. https://doi.org/10.3390/app10207020

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