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Effectiveness of a Serious Game for Cognitive Training in Chronic Stroke Survivors with Mild-to-Moderate Cognitive Impairment: A Pilot Randomized Controlled Trial

1
College of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA
2
Department of Rehabilitation and Movement Sciences, Rutgers University, New Brunswick, NJ 07107, USA
3
Woorisoft, Daegu 42781, Korea
4
Heeyeon Rehabilitation Hospital, Changwon 51420, Gyeongsangnam-do, Korea
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(19), 6703; https://doi.org/10.3390/app10196703
Received: 27 August 2020 / Revised: 21 September 2020 / Accepted: 22 September 2020 / Published: 25 September 2020
(This article belongs to the Section Applied Biosciences and Bioengineering)
Previous cognitive training games for stroke survivors required the close supervision of therapists. We aim to demonstrate the preliminary therapeutic effectiveness of Neuro-World, serious mobile games for cognitive training, in chronic stroke survivors with mild-to-moderate cognitive impairment without therapist supervision. For that, we conducted a randomized, controlled clinical trial at a single long-term care rehabilitation center with 50 stroke survivors in the chronic stage with mild-to-moderate cognitive impairment. Participants were randomized to standard medical care (n = 25) or standard medical care plus administration of Neuro-World (n = 25) over 12 weeks. A two-way mixed model ANOVA and Tukey’s post hoc tests identified significant differences in outcomes between the experimental and the control groups at post-intervention but not at baseline. Within the experimental group, there were statistically significant improvements in all the outcomes except for the language category of the Mini-Mental State Examination and Digit Forward Span. The improvements were clinically significant for the total Mini-Mental State Examination, Digit Forward Span, and Digit Backward Span. Within the control group, there were no improvements in any of the outcomes. The practice of Neuro-World led to significant improvements in cognitive function and marginal mitigation of depressive symptoms in chronic stroke survivors with mild-to-moderate cognitive impairment. View Full-Text
Keywords: serious games; mobile games; cognitive impairment; cognitive rehabilitation; stroke survivors; chronic stage serious games; mobile games; cognitive impairment; cognitive rehabilitation; stroke survivors; chronic stage
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MDPI and ACS Style

Jung, H.-T.; Daneault, J.-F.; Nanglo, T.; Lee, H.; Kim, B.; Kim, Y.; Lee, S.I. Effectiveness of a Serious Game for Cognitive Training in Chronic Stroke Survivors with Mild-to-Moderate Cognitive Impairment: A Pilot Randomized Controlled Trial. Appl. Sci. 2020, 10, 6703. https://doi.org/10.3390/app10196703

AMA Style

Jung H-T, Daneault J-F, Nanglo T, Lee H, Kim B, Kim Y, Lee SI. Effectiveness of a Serious Game for Cognitive Training in Chronic Stroke Survivors with Mild-to-Moderate Cognitive Impairment: A Pilot Randomized Controlled Trial. Applied Sciences. 2020; 10(19):6703. https://doi.org/10.3390/app10196703

Chicago/Turabian Style

Jung, Hee-Tae, Jean-Francois Daneault, Tenzin Nanglo, Hyunsuk Lee, Byeongil Kim, Yangsoo Kim, and Sunghoon I. Lee 2020. "Effectiveness of a Serious Game for Cognitive Training in Chronic Stroke Survivors with Mild-to-Moderate Cognitive Impairment: A Pilot Randomized Controlled Trial" Applied Sciences 10, no. 19: 6703. https://doi.org/10.3390/app10196703

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