Prior research reveal that low-viscosity resin is able to significantly penetrate initial caries lesions, which leads to their stabilization. The objective of the present report is to assess the shear bond strength (SBS) of orthodontic brackets bonded with different adhesives to demineralized enamel treated with a low-viscosity resin infiltrant. It also aims to compare the achieved bond strengths to those achieved in relation to sound enamel (SE). A total of 48 newly extracted third molars were collected, distributed in four groups (n=12), covered with a nail varnish, with 4 x 4 mm of uncoated area, immersed in Buskes demineralizing solution (14 days, 37 °C) or remained untreated. Group I: SE + Transbond XT; Group II: demineralized enamel (DE) + ICON + Transbond XT; Group III: DE + ICON + Scotchbond Universal; Group IV: DE + ICON + Assure PLUS. SBS was quantified in megapascals (MPa) and statistically analyzed (ANOVA, p
≤ 0.05). The mode of failure was assessed microscopically (10 x magnification). The highest SBS detected was in Group IV, and the difference was statistically significant (F = 14.37; p
= 0.000). Treatment with a resin infiltrant on DE does not impair the shear bond strength when compared to SE, although it does produce a significantly higher strength when combined with Assure PLUS.
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