Primary Arterial Hypertension Associated with Cognitive Dysfunction in Young Adults: Results from a Cross-Sectional Controlled Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Setting and Participants
2.2. Anthropometric and Blood Pressure Measurement
2.3. Cognitive Outcomes
- Match to Sample Visual Search (MTS, attention and processing speed)
- Paired Associates Learning (PAL, visual memory and new learning)
- Reaction Time Task (RTI, motor and mental response speed, movement time, reaction time, response accuracy and impulsivity)
- Rapid Visual Information Processing (RVP, sustained attention)
- Stockings of Cambridge (SOC, spatial planning, working memory)
- Spatial Span (SSP, working memory capacity)
- Spatial Working Memory (SWM, working memory, strategy use)
2.4. Statistical Analysis
2.5. Ethics
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
Match to Sample Visual Search (MTS) |
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Domains: attention and processing speed. Description: One pattern is displayed in the middle of the screen. The participant must select a matching pattern appearing in other boxes on the screen as rapidly as possible. Variables:
|
Paired Associates Learning (PAL) |
Domains: visual memory and new learning. Description: The participant selects boxes with a matching pattern based on previously shown information. Variables:
|
Reaction Time Task (RTI) |
Domains: motor and mental response speed, movement time, reaction time, response accuracy and impulsivity. Description: the participant holds a button at the bottom of the screen and has to react to flashing circles above as soon as possible (release the button and tap the flashing circle). Variables:
|
Rapid Visual Information Processing (RVP) |
Domain: sustained attention. Description: participants have to press a button when they detect a target number sequence within a box of changing digits. Variables:
|
Stockings of Cambridge (SOC) |
Domains: spatial planning and working memory. Description: participants move virtual balls to solve a spatial problem. Variables:
|
Spatial Span (SSP) |
Domain: working memory capacity. Description: participants must recall a sequence of boxes changing color. Variable:
|
Spatial Working Memory (SWM) |
Domains: working memory, strategy use. Description: participants must find hidden tokens across a set of colored boxes on the screen. Variables:
|
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Characteristic | Healthy Controls (Median (IQR) or Mean (SD)), n = 22 | Hypertension Group (Median (IQR) or Mean (SD)), n = 33 | Independent Sample Test Result and p Value |
---|---|---|---|
Age, years | 36.1 (27.5–39.8) | 38.8 (33.2–41.6) | Z = −1.581, p = 0.114 |
Height, cm | 177.2 (6.8) | 179.6 (8.2) | t = −1.102, p = 0.276 |
Weight, kg | 76.3 (12.1) | 97.0 (12.4) | t = −6.021, p < 0.001 |
BMI, kg/m2 | 24.2 (3.1) | 30.2 (4.7) | t = −5.152, p < 0.001 |
Waist, cm | 89.6 (14.6) | 103.8 (11.8) | t = −3.831, p < 0.001 |
Hip, cm | 99.8 (8.6) | 111.9 (10) | t = −4.281, p < 0.001 |
Waist-hip ratio | 0.9 (0.8–1.0) | 0.9 (0.9–1) | Z = −1.213, p = 0.225 |
Waist-height ratio | 0.5 (0.1) | 0.6 (0.1) | t = −3.551, p = 0.001 |
SBP, mmHg | 117 (108.9–124.1) | 131 (122.3–145.3) | Z = −4.038, p < 0.001 |
DBP, mmHg | 72.5 (67.4–75.6) | 86 (76–96) | Z = −3.833, p < 0.001 |
PP, mmHg | 43.6 (6.5) | 48.6 (9.3) | t = −2.181, p = 0.034 |
24-h SBP, mmHg | 112.9 (6.6) | 128.0 (11.9) | t = −5.879, p < 0.001 |
24-h DBP, mmHg | 67.5 (65.0–72.5) | 79.5 (75.0–86.3) | Z = −4.924, p < 0.001 |
24-h MAP, mmHg | 88.7 (4.8) | 102.3 (9.6) | t = −6.828, p < 0.001 |
Daytime SBP, mmHg | 116.7 (7.8) | 130.6 (12.3) | t = −5.015, p < 0.001 |
Daytime DBP, mmHg | 71.4 (5.3) | 83.2 (9.2) | t = −5.913, p < 0.001 |
Daytime MAP, mmHg | 92.2 (5.5) | 105.0 (9.9) | t = −5.999, p < 0.001 |
Nighttime SBP, mmHg | 102.2 (6.5) | 117.7 (11.9) | t = −6.059, p < 0.001 |
Nighttime DBP, mmHg | 59.5 (53.5–66.5) | 70.5 (66.0–73.5) | Z = −4.324, p < 0.001 |
Nighttime MAP, mmHg | 80.0 (73.5–83.0) | 91.5 (86.0–95.0) | Z = −4.952, p < 0.001 |
SBP dipping, % | 12.3 (5.9) | 9.7 (6.0) | t = 1.500, p = 0.140 |
DBP dipping, % | 16.3 (8.2) | 14.3 (5.8) | t = 1.045, p = 0.301 |
PWV, m/s | 6.9 (6.0–7.7) | 7.9 (7.2–9.2) | Z = −3.172, p = 0.002 |
cSBP, mmHg | 103 (99.8–108.3) | 119 (108.5–134.0) | Z = −4.538, p < 0.001 |
cDBP, mmHg | 72.5 (67.5–75.8) | 81 (73–94) | Z = −3.733, p < 0.001 |
cPP, mmHg | 33.0 (27.0–35.3) | 38 (32–43) | Z = −2.891, p = 0.004 |
PPA (cPP/PP) | 0.7 (0.1) | 0.8 (0.2) | t = −1.808, p = 0.076 |
Neuropsychological Measure | Healthy Controls (Median (IQR) or Mean (SD)), n = 22 | Hypertension Group (Median (IQR) or Mean (SD)), n = 33 | Independent Sample Test Result and p Value |
---|---|---|---|
Paper-pencil assessment | |||
Categorical verbal fluency, points h | 22.6 (4.1) | 22.5 (6.6) | t = 0.095, p = 0.925 |
Phonemic verbal fluency, points h | 13.2 (4.1) | 11.7 (5.0) | t = 1.192, p = 0.239 |
VLS immediate recall, points h | 15.6 (2.4) | 15.8 (3.1) | t = −0.223, p = 0.825 |
VLS 30 min recall, points h | 14.5 (2.6) | 13.4 (3.3) | t = 1.234, p = 0.223 |
VLS 24 h recall, points h | 14.0 (2.9) | 12.8 (3.6) | t = 1.373, p = 0.176 |
Verbal IQ, points h | 117.4 (8.9) | 112.7 (12.1) | t = 1.558, p = 0.125 |
Nonverbal IQ, points h | 116 (108.5–121.3) | 112 (99.5–119.0) | Z = −1.204, p = 0.229 |
IQ, points h | 121 (108.5–126.5) | 115 (104.5–124.5) | Z = −1.385, p = 0.166 |
Computerized assessment | |||
Match to Sample Visual Search | |||
MTSPS82, ms c | 2052.2 (1547.0–2548.8) | 2116.3 (1868.2–2507.7) | Z = −0.825, p = 0.410 |
MTSRCAMD, ms l | 2033.1 (466.4) | 2189.9 (450.9) | t = −1.246, p = 0.218 |
Paired Associates Learning | |||
PALFAMS28, points h | 17 (12.0–18.3) | 13 (10.5–17.0) | Z = −1.812, p = 0.070 |
PALTEA28, points l | 3.5 (1.8–12.3) | 10 (3.5–15.0) | Z = −1.747, p = 0.081 |
Reaction Time Task | |||
RTIFMDMT, ms l | 251.8 (235.1–274.4) | 275 (254.0–319.3) | Z = −2.019, p = 0.044 * |
RTIFMDRT, ms l | 341.8 (321.3–393.6) | 361 (345.0–403.3) | Z = −1.822, p = 0.068 |
RTISMDMT, ms l | 253.5 (234.3–278.3) | 260 (213.5–309.5) | Z = −0.472, p = 0.637 |
RTISMDRT, ms l | 304.5 (295.1–330.1) | 327 (310.5–356.5) | Z = −2.509, p = 0.012 * |
Rapid Visual Information Processing | |||
RVPA, arb. unit h | 0.929 (0.029) | 0.900 (0.052) | t = 2.373, p = 0.021 * |
RVPMDL, ms l | 421.5 (397.6–474.3) | 439 (404–466.8) | Z = −1.005, p = 0.315 |
RVPPFA, arb. unit l | 0 (0–0.01) | 0.01 (0–0.01) | Z = −2.052, p = 0.040 * |
Stockings of Cambridge | |||
SOCITMD5, ms l | 11137 (8361.8–18643) | 9825.5 (5990.5–14996) | Z = −1.495, p = 0.135 |
SOCMNM5, points l | 5.5 (5–6.8) | 5.5 (5–6.5) | Z = −0.202, p = 0.840 |
SOCPSMMT, points h | 10 (9–11) | 9 (9–11) | Z = −0.747, p = 0.455 |
SOCSTMD5, ms l | 0 (0–658.1) | 0 (0–235) | Z = −0.442, p = 0.658 |
Spatial Span | |||
SSPFSL, points h | 6 (6–7) | 7 (6–7.5) | Z = −0.392, p = 0.695 |
Spatial Working Memory | |||
SWMBE4, points l | 0 (0–0) | 0 (0–0) | Z = −0.477, p = 0.634 |
SWMBE468, points l | 4 (0–15) | 1 (0–9.5) | Z = −1.238, p = 0.216 |
SWMBE6, points l | 0 (0–2.8) | 0 (0–2) | Z = −0.622, p = 0.534 |
SWMBE8, points l | 3 (0–13) | 0 (0–7.5) | Z = −1.118, p = 0.264 |
SWMS, arb. unit l | 6.5 (5.8–9) | 5 (3–8) | Z = −1.565, p = 0.118 |
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Puteikis, K.; Ažukaitis, K.; Dadurkevičienė, D.; Simanauskas, K.; Šileikienė, V.; Jankauskienė, A.; Mameniškienė, R. Primary Arterial Hypertension Associated with Cognitive Dysfunction in Young Adults: Results from a Cross-Sectional Controlled Study. Behav. Sci. 2024, 14, 321. https://doi.org/10.3390/bs14040321
Puteikis K, Ažukaitis K, Dadurkevičienė D, Simanauskas K, Šileikienė V, Jankauskienė A, Mameniškienė R. Primary Arterial Hypertension Associated with Cognitive Dysfunction in Young Adults: Results from a Cross-Sectional Controlled Study. Behavioral Sciences. 2024; 14(4):321. https://doi.org/10.3390/bs14040321
Chicago/Turabian StylePuteikis, Kristijonas, Karolis Ažukaitis, Danguolė Dadurkevičienė, Kazys Simanauskas, Vaida Šileikienė, Augustina Jankauskienė, and Rūta Mameniškienė. 2024. "Primary Arterial Hypertension Associated with Cognitive Dysfunction in Young Adults: Results from a Cross-Sectional Controlled Study" Behavioral Sciences 14, no. 4: 321. https://doi.org/10.3390/bs14040321
APA StylePuteikis, K., Ažukaitis, K., Dadurkevičienė, D., Simanauskas, K., Šileikienė, V., Jankauskienė, A., & Mameniškienė, R. (2024). Primary Arterial Hypertension Associated with Cognitive Dysfunction in Young Adults: Results from a Cross-Sectional Controlled Study. Behavioral Sciences, 14(4), 321. https://doi.org/10.3390/bs14040321