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Behavioral Sciences
Volume 12
Issue 8
10.3390/bs12080287
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Article

Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion

by
Apsorn Sattayakhom
1,2,
Kosin Kalarat
3,
Thatdao Rakmak
4,
Sompol Tapechum
5,
Arnaud Monteil
6,
Chuchard Punsawad
7,
Sarawoot Palipoch
7 and
Phanit Koomhin
2,7,*
1
School of Allied Health Sciences, Walailak University, Nakhonsithammarat 80160, Thailand
2
Center of Excellence in Innovation on Essential Oil, Walailak University, Nakhonsithammarat 80160, Thailand
3
School of Informatics, Walailak University, Nakhonsithammarat 80160, Thailand
4
School of Liberal Arts, Walailak University, Nakhonsithammarat 80160, Thailand
5
Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
6
Institutde Génomique Fonctionnelle, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France
7
School of Medicine, Walailak University, Nakhonsithammarat 80160, Thailand
*
Author to whom correspondence should be addressed.
Behav. Sci. 2022, 12(8), 287; https://doi.org/10.3390/bs12080287
Submission received: 7 July 2022 / Revised: 9 August 2022 / Accepted: 12 August 2022 / Published: 14 August 2022
(This article belongs to the Section Experimental and Clinical Neurosciences)
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Abstract

Ceftriaxone (CTX) exerts a neuroprotective effect by decreasing glutamate excitotoxicity. We further studied the underlying mechanisms and effects of CTX early post-treatment on behavior in a cerebral hypoperfusion rats. The rats’ common carotid arteries (2VO) were permanently ligated. CTX was treated after ischemia. Biochemical studies were performed to assess antioxidative stress and inflammation. Behavioral and histological studies were then tested on the ninth week after vessel ligation. The 2VO rats showed learning and memory deficits as well as working memory impairments without any motor weakness. The treatment with CTX was found to attenuate white matter damage, MDA production, and interleukin 1 beta and tumor necrosis factor alpha production, mainly in the hippocampal area. Moreover, CTX treatment could increase the expression of glia and the glial glutamate transporters, and the neuronal glutamate transporter. Taken together, our data indicate the neuroprotective mechanisms of CTX involving the upregulation of glutamate transporters’ expression. This increased expression contributes to a reduction in glutamate excitotoxicity and oxidative stress as well as pro-inflammatory cytokine production, thus resulting in the protection of neurons and tissue from further damage. The present study highlights the mechanism of the effect of CTX treatment and of the underlying ischemia-induced neuronal damage.
Keywords: ceftriaxone; white matter damage; oxidative stress; inflammation ceftriaxone; white matter damage; oxidative stress; inflammation

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MDPI and ACS Style

Sattayakhom, A.; Kalarat, K.; Rakmak, T.; Tapechum, S.; Monteil, A.; Punsawad, C.; Palipoch, S.; Koomhin, P. Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion. Behav. Sci. 2022, 12, 287. https://doi.org/10.3390/bs12080287

AMA Style

Sattayakhom A, Kalarat K, Rakmak T, Tapechum S, Monteil A, Punsawad C, Palipoch S, Koomhin P. Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion. Behavioral Sciences. 2022; 12(8):287. https://doi.org/10.3390/bs12080287

Chicago/Turabian Style

Sattayakhom, Apsorn, Kosin Kalarat, Thatdao Rakmak, Sompol Tapechum, Arnaud Monteil, Chuchard Punsawad, Sarawoot Palipoch, and Phanit Koomhin. 2022. "Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion" Behavioral Sciences 12, no. 8: 287. https://doi.org/10.3390/bs12080287

APA Style

Sattayakhom, A., Kalarat, K., Rakmak, T., Tapechum, S., Monteil, A., Punsawad, C., Palipoch, S., & Koomhin, P. (2022). Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion. Behavioral Sciences, 12(8), 287. https://doi.org/10.3390/bs12080287

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