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Volume 13
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10.3390/medsci13020073
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Article

The Impact of Epithelial Inflammation in Membrane Remnants on the Outcome of Tympanoplasty

by
María Fernanda Galindo-Tapia
1,
Alejandro Esteban Deras-Quiñones
2,
Itzel Maria Montoya-Fuentes
2,
Eduardo Osiris Madrigal-Santillán
3,
Ángel Morales-González
4,
Naria A. Flores-Fuentes
4,
Liliana Anguiano-Robledo
5,
Raúl Rojas-Martínez
3,
Beatriz Montaño-Velázquez
1,* and
José A. Morales-González
3,*
1
Instituto Mexicano del Seguro Social, Centro Médico Nacional la Raza, Hospital General “Dr. Gaudencio González Garza”, Servicio de Otorrinolaringología, Mexico City 02990, Mexico
2
Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades “Dr. Antonio Fraga Mouret”, Servicio de Patología, Mexico City 02990, Mexico
3
Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, Alcaldía Miguel Hidalgo, Mexico City 11340, Mexico
4
Escuela Superior de Cómputo, Instituto Politécnico Nacional, Unidad Profesional “A. López Mateos”, Mexico City 07738, Mexico
5
Laboratorio de Farmacología Molecular, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Mexico City 11340, Mexico
*
Authors to whom correspondence should be addressed.
Med. Sci. 2025, 13(2), 73; https://doi.org/10.3390/medsci13020073
Submission received: 13 April 2025 / Revised: 3 June 2025 / Accepted: 4 June 2025 / Published: 7 June 2025
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Abstract

Background: Chronic otitis media (COM) with tympanic perforation sometimes requires tympanoplasty. Many factors can interfere with surgical success; however, the histological status of the remaining epithelium of the perforation has not been studied as a risk factor for surgical failure. Methods: This was an observational, longitudinal, and analytical study in patients with COM, candidates for tympanoplasty who met the inclusion criteria, between August and December 2024. Tympanoplasty was performed, and the tympanic ring epithelium was sent for histological analysis. After 30 days, closure or non-closure of the perforation was determined, and the results were collected. Descriptive and analytical statistics were performed according to data distribution using the SPSS 26.0 statistical package. Results: Twenty subjects were included, 80% with tubal dysfunction, 60% with central perforation, and 65% with medium-sized. In total, 13 were successful, and 7 failed. Histopathological analysis revealed dystrophic calcification, chronic lymphocytic infiltrate, histiocytic infiltrate, fibrosis, loose keratin sheets, metaplasia, and spongiosis. The logistic regression model showed an OR of 7.3 for marginal perforation and 3.4 for the OPSS score. Of the patients with surgical failure, 57.4% had epithelial inflammation. Conclusions: epithelial inflammation affected surgical success in more than 50%.
Keywords: chronic otitis media; tympanic perforation; tympanoplasty; epithelial inflammation chronic otitis media; tympanic perforation; tympanoplasty; epithelial inflammation

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MDPI and ACS Style

Galindo-Tapia, M.F.; Deras-Quiñones, A.E.; Montoya-Fuentes, I.M.; Madrigal-Santillán, E.O.; Morales-González, Á.; Flores-Fuentes, N.A.; Anguiano-Robledo, L.; Rojas-Martínez, R.; Montaño-Velázquez, B.; Morales-González, J.A. The Impact of Epithelial Inflammation in Membrane Remnants on the Outcome of Tympanoplasty. Med. Sci. 2025, 13, 73. https://doi.org/10.3390/medsci13020073

AMA Style

Galindo-Tapia MF, Deras-Quiñones AE, Montoya-Fuentes IM, Madrigal-Santillán EO, Morales-González Á, Flores-Fuentes NA, Anguiano-Robledo L, Rojas-Martínez R, Montaño-Velázquez B, Morales-González JA. The Impact of Epithelial Inflammation in Membrane Remnants on the Outcome of Tympanoplasty. Medical Sciences. 2025; 13(2):73. https://doi.org/10.3390/medsci13020073

Chicago/Turabian Style

Galindo-Tapia, María Fernanda, Alejandro Esteban Deras-Quiñones, Itzel Maria Montoya-Fuentes, Eduardo Osiris Madrigal-Santillán, Ángel Morales-González, Naria A. Flores-Fuentes, Liliana Anguiano-Robledo, Raúl Rojas-Martínez, Beatriz Montaño-Velázquez, and José A. Morales-González. 2025. "The Impact of Epithelial Inflammation in Membrane Remnants on the Outcome of Tympanoplasty" Medical Sciences 13, no. 2: 73. https://doi.org/10.3390/medsci13020073

APA Style

Galindo-Tapia, M. F., Deras-Quiñones, A. E., Montoya-Fuentes, I. M., Madrigal-Santillán, E. O., Morales-González, Á., Flores-Fuentes, N. A., Anguiano-Robledo, L., Rojas-Martínez, R., Montaño-Velázquez, B., & Morales-González, J. A. (2025). The Impact of Epithelial Inflammation in Membrane Remnants on the Outcome of Tympanoplasty. Medical Sciences, 13(2), 73. https://doi.org/10.3390/medsci13020073

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