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Open AccessCommunication

A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle

1
Key Laboratory of Beef Cattle Genetics and Breeding in Ministry of Agriculture and Rural Agriculture, Branch of Animal Husbandry, Jilin Academy of Agricultural Sciences, Changchun 130033, China
2
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China
3
The Animal Husbandry Research Institute of Guangxi Zhuang Autonomous Region, Nanning 53001, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Animals 2019, 9(8), 554; https://doi.org/10.3390/ani9080554
Received: 2 July 2019 / Revised: 1 August 2019 / Accepted: 7 August 2019 / Published: 14 August 2019
(This article belongs to the Collection Applications of Quantitative Genetics in Livestock Production)
A missense mutation (NC_037329.1: g.136054902 C > G: p. Ala69Gly) was identified in the heat shock protein family B (small) member 7 (HSPB7) gene in indicine cattle, which might be a candidate mutation associated with the heat tolerance. Here, Polymerase Chain Reaction and DNA sequencing methods were used to detect this mutation in 774 individuals belonging to 32 Chinese indigenous cattle breeds. The distribution of alleles of NC_037329.1: g.136054902 C > G displays significant geographical difference across native Chinese cattle breeds and cattle carrying allele G distributed in regions with higher mean annual temperature, relative humidity, and temperature humidity index. Our results demonstrate that the mutation of the HSPB7 gene in Chinese indicine cattle might be a candidate gene associated with the heat tolerance.
The small heat shock proteins (HSPB) are expressed in response to heat stress, and the heat shock protein family B (small) member 7 (HSPB7) gene has been reported to play an important role in heat tolerance pathways. Only a missense mutation (NC_037329.1: g.136054902 C > G: p.Ala69Gly) was identified in the HSPB7 gene in indicine cattle, which might be a candidate mutation associated with the heat tolerance. Here, we explore the allele frequency of this mutation in 774 individuals belonging to 32 Chinese indigenous cattle breeds using polymerase chain reaction (PCR) and DNA sequencing methods. The distribution of alleles of NC_037329.1: g.136054902 C > G displays significant geographical difference across native Chinese cattle breeds that the allele C was dominant in northern cattle groups, while allele G was dominant in southern indicine cattle groups. Additionally, the association analysis indicated that the G allele was significantly associated with mean annual temperature (T), relative humidity (RH), and temperature humidity index (THI) (p < 0.01), suggesting that cattle carrying allele G were distributed in regions with higher T, RH, and THI. Our results demonstrate that the mutation of the HSPB7 gene in Chinese indicine cattle might be a candidate gene associated with the heat tolerance. View Full-Text
Keywords: Chinese cattle; HSPB7 gene; heat tolerance Chinese cattle; HSPB7 gene; heat tolerance
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MDPI and ACS Style

Zeng, L.; Cao, Y.; Wu, Z.; Huang, M.; Zhang, G.; Lei, C.; Zhao, Y. A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle. Animals 2019, 9, 554. https://doi.org/10.3390/ani9080554

AMA Style

Zeng L, Cao Y, Wu Z, Huang M, Zhang G, Lei C, Zhao Y. A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle. Animals. 2019; 9(8):554. https://doi.org/10.3390/ani9080554

Chicago/Turabian Style

Zeng, Lulan; Cao, Yanhong; Wu, Zhuyue; Huang, Mingguang; Zhang, Guoliang; Lei, Chuzhao; Zhao, Yumin. 2019. "A Missense Mutation of the HSPB7 Gene Associated with Heat Tolerance in Chinese Indicine Cattle" Animals 9, no. 8: 554. https://doi.org/10.3390/ani9080554

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