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Open AccessArticle

Comparative Analysis of the aquaporin Gene Family in 12 Fish Species

by Jun Cao 1,* and Feng Shi 2
1
Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China
2
Corporation of Lvdou Biopharmaceuticals, Binzhou 256600, China
*
Author to whom correspondence should be addressed.
Animals 2019, 9(5), 233; https://doi.org/10.3390/ani9050233
Received: 17 April 2019 / Revised: 10 May 2019 / Accepted: 11 May 2019 / Published: 13 May 2019
(This article belongs to the Section Animal Genetics and Genomics)
Aquaporins (Aqps) are a group of membrane proteins. In this study, 166 Aqp genes were identified in 12 fish species. Gene organization, motif distribution, recombination, and selection pressure were performed to investigate their evolutionary characteristics. In addition, expression profiles of Aqps were also examined under pathogens infection and organophosphorus pesticide stress. This study will provide a useful reference for further functional study.
Aquaporins (Aqps) are a class of water channel proteins that play key roles in many physiological functions and cellular processes. Here, we analyzed 166 putative Aqp genes in 12 fish species and divided them into four groups. Gene organization and motif distribution analyses suggested potentially conserved functions in each group. Several recombination events were identified in some members, which accelerate their divergence in evolution. Furthermore, a few positive selection sites were identified, and mutations at these sites could alter the stability of Aqp proteins. In addition, expression profiles of some Aqp genes under pathogen infection and organophosphorus pesticide stress were also investigated. The result implied that several Aqp genes may affect different immune responses and osmoregulation. This study provides a comparative analysis of the fish Aqp gene family to facilitate further functional analyses. View Full-Text
Keywords: intragenic recombination; evolution; selective pressure; expression; organophosphorus pesticide intragenic recombination; evolution; selective pressure; expression; organophosphorus pesticide
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Cao, J.; Shi, F. Comparative Analysis of the aquaporin Gene Family in 12 Fish Species. Animals 2019, 9, 233.

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