Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Ethical Statement
2.2. Study Subjects
2.3. Anesthetic and Analgesic Protocol/Management
2.4. Surgical Procedure
2.5. Data Collection and Evaluation Times
2.6. Recovery Quality and Postoperative Analgesic Management
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Evaluation Time Points | |
---|---|
T0 | Baseline values |
T1 | Ten minutes after administration of premedication |
T2 | Shortly before induction |
T3 | Immediately after intubation |
T4 | Twenty minutes after EtDes 5.5% |
T5 | Skin incision |
T6 | Right ovarian ligament traction force |
T7 | Right ovarian ligament resection |
T8 | Left ovarian ligament traction force |
T9 | Left ovarian ligament resection |
T10 | Fascia suture |
T11 | Skin suture |
Category | Expressions | Score |
---|---|---|
Spontaneous posture | Standing | 0 |
Tired but standing | 1 | |
Lying but able to rise | 2 | |
Lying but difficulty rising | 3 | |
Unable to rise | 4 | |
Palpebral Reflex | Brisk | 0 |
Slow but with full corneal sweep | 1 | |
Slow but with only partial corneal sweep | 2 | |
Absent | 3 | |
Eye position | Central | 0 |
Rotated forwards/downwards but not obscured by third eyelid | 1 | |
Rotated forwards/downwards and obscured by third eyelid | 2 | |
Jaw and tongue relaxation | Normal jaw tone/(strong gag reflex) | 0 |
Reduced tone, (but still moderate gag reflex) | 1 | |
Much reduced tone, slight gag reflex | 2 | |
Loss of jaw tone and no gag reflex | 3 | |
Response to noise (handclap) | Normal startle reaction (head turn towards noise/cringe) | 0 |
Reduced startle reaction (reduced head turn/minimal cringe) | 1 | |
Minimal startle reaction | 2 | |
Absent reaction | 3 | |
Resistance when laid into lateral recumbency | Much struggling, perhaps not allowing this positioning | 0 |
Some struggling, but allowing this positioning | 1 | |
Minimal struggling/permissive | 2 | |
No struggling | 3 | |
General appearance attitude | Excitable | 0 |
Awake and normal | 1 | |
Tranquil | 2 | |
Stuporous | 3 |
Category | Expressions | Score |
---|---|---|
Excellent | Intubation successful in one attempt without physical reaction to intubation | 0 |
Good | Intubation successful in one attempt with physical response to intubation | 1 |
Satisfactory | Intubation successful after more than one attempt with or without physical response to intubation | 2 |
Poor | Intubation impossible | 3 |
Factors | Assessments | Score |
---|---|---|
Struggling | None | 0 |
Transient, easily calmed by the investigator’s voice | 1 | |
Prolonged (>1 min) | 2 | |
Persistent (or requiring restraint) | 3 | |
Excitement | None | 0 |
Transient, easily calmed by the investigator’s voice | 1 | |
Prolonged (>1 min) | 2 | |
Persistent (or requiring restraint) | 3 | |
Paddling | None | 0 |
Transient, easily calmed by the investigator’s voice | 1 | |
Prolonged (>1 min) | 2 | |
Persistent (or requiring restraint) | 3 | |
Flailing | None | 0 |
Transient, easily calmed by the investigator’s voice | 1 | |
Prolonged (>1 min) | 2 | |
Persistent (or requiring restraint) | 3 | |
Vocalization | None | 0 |
Transient, easily calmed by the investigator’s voice | 1 | |
Prolonged (>1 min) | 2 | |
Persistent (or requiring restraint) | 3 | |
Administration of rescue drugs | Not given | 0 |
Given | 3 |
SHORT FORM OF THE GLASGOW COMPOSITE PAIN SCALE | |||
Dog’s name _______________________________________________ | |||
Hospital Number _________ | Date / / | Time __________ | |
Surgery Yes/No (delete as appropriate) | |||
Procedure or Condition ___________________________________________ | |||
In the sections below please circle the appropriate score in each list and sum these to give the total score | |||
| |||
(i) | (ii) | ||
Quiet | 0 | Ignoring any wound or painful area | 0 |
Crying or whimpering | 1 | Looking at wound or painful area | 1 |
Groaning | 2 | Licking wound or painful area | 2 |
Screaming | 3 | Rubbing wound or painful area | 3 |
Chewing wound or painful area | 4 | ||
__________________________________________________________________________ | |||
In the case of spinal, pelvic or multiple limb fractures, or where assistance is required to aid locomotion do not carry out section B and proceed to C Please tick if this is the case ◻ then proceed to C | |||
|
| ||
When the dog rises/walks is it? | Does it? | ||
(iii) | (iv) | ||
Normal | 0 | Do nothing | 0 |
Lame | 1 | Look round | 1 |
Slow or reluctant | 2 | Flinch | 2 |
Stiff | 3 | Growl or guard area | 3 |
It refuses to move | 4 | Snap | 4 |
Cry | 5 | ||
__________________________________________________________________________ | |||
| |||
Is the dog? | Is the dog? | ||
(v) | (vi) | ||
Happy and content or happy and bouncy | 0 | Comfortable | 0 |
Quiet | 1 | Unsettled | 1 |
Indifferent or non-responsive to surroundings | 2 | Restless | 2 |
Nervous or anxious or fearful | 3 | Hunched or tense | 3 |
Depressed or non-responsive to stimulation | 4 | Rigid | 4 |
© University of Glasgow | Total Score (i + ii + iii + iv + v + vi) = _______ |
Maropi Group | Metha Group | |||
---|---|---|---|---|
VT (mL) | VM (Lt) | VT (mL) | VM (Lt) | |
T3 | 192.13 ± 31.78 | 1.93 ± 2.47 | 195.13 ± 34.81 | 1.90 ± 3.44 |
T4 | 192.72 ± 30.74 | 1.90 ± 3.91 | 195.72 ± 33.77 | 1.87 ± 2.88 |
T5 | 193.08 ± 29.63 | 1.88 ± 2.15 | 196.08 ± 32.66 | 1.85 ± 3.12 |
T6 | 191.75 ± 26.08 | 1.95 ± 2.95 | 194.75 ± 29.11 | 1.92 ± 2.92 |
T7 | 193.23 ± 31.78 | 1.90 ± 2.14 | 196.23 ± 34.81 | 1.87 ± 3.11 |
T8 | 191.00 ± 37.14 | 1.97 ± 3.97 | 194.00 ± 30.17 | 1.94 ± 2.94 |
T9 | 191.65 ± 31.78 | 1.91 ± 3.12 | 195.65 ± 34.81 | 1.88 ± 3.09 |
T10 | 193.17 ± 30.78 | 1.89 ± 2.79 | 196.17 ± 34.81 | 1.86 ± 2.77 |
T11 | 194.13 ± 24.34 | 1.88 ± 2.42 | 197.13 ± 27.37 | 1.86 ± 3.40 |
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Cubeddu, F.; Masala, G.; Sotgiu, G.; Mollica, A.; Versace, S.; Careddu, G.M. Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone. Animals 2023, 13, 2388. https://doi.org/10.3390/ani13142388
Cubeddu F, Masala G, Sotgiu G, Mollica A, Versace S, Careddu GM. Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone. Animals. 2023; 13(14):2388. https://doi.org/10.3390/ani13142388
Chicago/Turabian StyleCubeddu, Francesca, Gerolamo Masala, Giovanni Sotgiu, Alessandra Mollica, Sylvia Versace, and Giovanni Mario Careddu. 2023. "Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone" Animals 13, no. 14: 2388. https://doi.org/10.3390/ani13142388