Multi-Injection Pharmacokinetics of Meloxicam in Kemp’s Ridley (Lepidochelys kempii) and Green (Chelonia mydas) Sea Turtles after Subcutaneous Administration
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Pharmacokinetic Parameter | Green MLX a Mean ± SD | Green MLX b Mean ± SD | Kemp MLX a Mean ± SD | Kemp MLX c Mean ± SD |
---|---|---|---|---|
Terminal half-life * (h) | † | 23.71 ± 2.81 | 5.51 ± 1.58 | 7.18 ± 2.21 |
Elimination rate constant λz (1/h) | 0.02 ± 0.01 | 0.03 ± 0.003 | 0.13 ± 0.04 | 0.10 ± 0.03 |
Tmax (h) | 0.81 ± 0.26 | 1.29 ± 1.35 | 0.57 ± 0.31 | 0.75 ± 0.27 |
Cmax (µg/mL) | 9.35 ± 1.61 | 9.03 ± 2.59 ‡ | 6.76 ± 3.13 | 4.77 ± 0.26 |
AUC0–∞ (h∙µg/mL) | 286.10 ± 212.71 | 185.97 ± 70.69 ‡ | 35.55 ± 11.56 | 32.86 ± 7.70 |
MRT0–∞(h) | 50.43 ± 29.32 | 31.29 ± 3.94 ‡ | 7.21 ± 1.96 | 9.73 ± 1.27 |
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Norton, T.M.; Clauss, T.; Overmeyer, R.; Stowell, S.; Kaylor, M.; Cox, S. Multi-Injection Pharmacokinetics of Meloxicam in Kemp’s Ridley (Lepidochelys kempii) and Green (Chelonia mydas) Sea Turtles after Subcutaneous Administration. Animals 2021, 11, 3522. https://doi.org/10.3390/ani11123522
Norton TM, Clauss T, Overmeyer R, Stowell S, Kaylor M, Cox S. Multi-Injection Pharmacokinetics of Meloxicam in Kemp’s Ridley (Lepidochelys kempii) and Green (Chelonia mydas) Sea Turtles after Subcutaneous Administration. Animals. 2021; 11(12):3522. https://doi.org/10.3390/ani11123522
Chicago/Turabian StyleNorton, Terry M., Tonya Clauss, Rachel Overmeyer, Stephanie Stowell, Michelle Kaylor, and Sherry Cox. 2021. "Multi-Injection Pharmacokinetics of Meloxicam in Kemp’s Ridley (Lepidochelys kempii) and Green (Chelonia mydas) Sea Turtles after Subcutaneous Administration" Animals 11, no. 12: 3522. https://doi.org/10.3390/ani11123522
APA StyleNorton, T. M., Clauss, T., Overmeyer, R., Stowell, S., Kaylor, M., & Cox, S. (2021). Multi-Injection Pharmacokinetics of Meloxicam in Kemp’s Ridley (Lepidochelys kempii) and Green (Chelonia mydas) Sea Turtles after Subcutaneous Administration. Animals, 11(12), 3522. https://doi.org/10.3390/ani11123522