Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, Italy
Department of Veterinary Science, University of Messina, 98168 Messina, Italy
Author to whom correspondence should be addressed.
These authors contributed equally.
Received: 31 March 2020 / Revised: 7 May 2020 / Accepted: 18 May 2020 / Published: 21 May 2020
Aflatoxin B1 (AFB1) is a mycotoxin commonly present in feed, characterized by several toxic effects. AFB1 has been described as being responsible for naturally occurring animal kidney disorders. In addition, AFB1 seems to have a neurotoxical effect that leads to memory impairment behavior. AFB1 toxicity involves the induction of the oxidative stress pathway, rising lipid peroxidation, and it decreases antioxidant enzyme levels. Hence, in our research, we wanted to evaluate the potential protective effects of quercetin in AFB1-mediated toxicity in the brain and the ameliorative effect on behavioral alterations. This antioxidant effect of quercetin in the brains of AFB1-intoxicated mice is reflected in better cognitive and spatial memory capacity, as well as a better profile of anxiety and lethargy disorders. In conclusion, our study suggests that quercetin exerts a preventive role against oxidative stress by promoting antioxidative defense systems and limiting lipid peroxidation.