Next Article in Journal
The Impact of Producing Type and Dietary Crude Protein on Animal Performances and Microbiota Together with Greenhouse Gases Emissions in Growing Pigs
Previous Article in Journal
Metabolomics Approach Explore Diagnostic Biomarkers and Metabolic Changes in Heat-Stressed Dairy Cows
Open AccessArticle

Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia

1
Department of Animal Nutrition, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, Hungary
2
Department of Mathematics and Informatics, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, Hungary
3
Department of Hippology, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, Hungary
4
Department of Animal Science, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, Hungary
*
Author to whom correspondence should be addressed.
Animals 2020, 10(10), 1743; https://doi.org/10.3390/ani10101743
Received: 31 July 2020 / Revised: 22 September 2020 / Accepted: 23 September 2020 / Published: 25 September 2020
(This article belongs to the Section Animal Genetics and Genomics)
For dog breeders, health is one of the main criteria when choosing a breeding animal; thus, selection for good anatomy is the key to reduce orthopedic disorders. In many dog breeds, radiographic screening for canine hip and elbow dysplasia is a compulsory test for breeding; however, these multifactorial traits are determined by genetic and environmental factors. Therefore, it is extremely difficult to eliminate these disorders from the population. In natural selection, such traits can be “purged” out of the population with inbreeding. The study aimed to examine the inbreeding-purge of canine hip and elbow dysplasia in the border collie breed. The main conclusion was that over-representation of homozygous individuals may have a positive effect on hip and elbow conformation.
Pedigree data of 13,339 border collie dog was collected along with canine hip dysplasia (CHD) and canine elbow dysplasia (CED) records (1352 CHD and 524 CED), and an inbreeding–purging (IP) model was created. Ancestral inbreeding coefficients were calculated by using a gene dropping simulation method with GRain 2.2 software. Cumulative logit models (CLM) for CHD and CED were fitted using a logit-link Poisson distribution and the classical (F_W), and ancestral inbreeding (F_BAL, F_KAL, and F_KAL_NEW) coefficients as linear regression coefficients. The effective population size was calculated from F_W and decreased in the examined period along with an increase of F_W; however, slight differences were found as a consequence of breeding dog imports. CHD values were lowered by the expansion of F_BAL, as the alleles had been inbred in the past. For CHD, signs of purging were obtained. There was a positive trend regarding the breeding activity (both sire and dam of the future litters should be screened and certified free from CHD and CED), as years of selection increased the frequency of alleles with favorable hip and elbow conformation. Division of the ancestral inbreeding coefficient showed that alleles that had been identical by descent (IBD) for the first time (F_KAL_NEW) had a negative effect on both traits, while F_KAL has shown favorable results for alleles IBD in past generations. Some authors had proven this phenomenon in captive populations or experimental conditions; however, no evidence of inbreeding purge has ever been described in dog populations. Despite the various breeding practices, it seems that alleles of these polygenic disorders could be successfully purged out of the population with long-term selection. View Full-Text
Keywords: border collie; inbreeding; purging; hip dysplasia; elbow dysplasia border collie; inbreeding; purging; hip dysplasia; elbow dysplasia
Show Figures

Figure 1

MDPI and ACS Style

Ács, V.; Kövér, G.; Farkas, J.; Bokor, Á.; Nagy, I. Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia. Animals 2020, 10, 1743.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop