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Article

Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2

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Department of Laboratory Medicine, Clinique Saint-Pierre, 1340 Ottignies-Louvain-la-Neuve, Belgium
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Namur Thrombosis and Hemostasis Center, Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, 5000 Namur, Belgium
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QUALIblood S.A., 5000 Namur, Belgium
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Department of Laboratory Medicine, CHU-UCL Namur, Université Catholique de Louvain, 5530 Yvoir, Belgium
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Department of Internal Medicine, Clinique Saint-Pierre, 1340 Ottignies-Louvain-la-Neuve, Belgium
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Department of Laboratory Medicine, Clinique Saint-Luc Bouge, 5004 Namur, Belgium
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Department of Internal Medicine, Clinique Saint-Luc Bouge, 5004 Namur, Belgium
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Department of Internal Medicine, CHU-UCL Namur, Université Catholique de Louvain, 5530 Yvoir, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Oliver Schildgen
Microorganisms 2021, 9(6), 1340; https://doi.org/10.3390/microorganisms9061340
Received: 7 June 2021 / Revised: 17 June 2021 / Accepted: 18 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue COVID-19: Antivirals and Vaccines)
Background: Little is known about potential confounding factors influencing the humoral response in individuals having received the BNT162b2 vaccine. Methods: Blood samples from 231 subjects were collected before and 14, 28, and 42 days following coronavirus disease 2019 (COVID-19) vaccination with BNT162b2. Anti-spike receptor-binding-domain protein (anti-Spike/RBD) immunoglobulin G (IgG) antibodies were measured at each time-point. Impact of age, sex, childbearing age status, hormonal therapy, blood group, body mass index and past-history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were assessed by multivariable analyses. Results and Conclusions: In naïve subjects, the level of anti-Spike/RBD antibodies gradually increased following administration of the first dose to reach the maximal response at day 28 and then plateauing at day 42. In vaccinated subjects with previous SARS-CoV-2 infection, the plateau was reached sooner (i.e., at day 14). In the naïve population, age had a significant negative impact on anti-Spike/RBD titers at days 14 and 28 while lower levels were observed for males at day 42, when corrected for other confounding factors. Body mass index (BMI) as well as B and AB blood groups had a significant impact in various subgroups on the early response at day 14 but no longer after. No significant confounding factors were highlighted in the previously infected group. View Full-Text
Keywords: SARS-CoV-2; vaccine; BNT162b2; antibody; serology; kinetic; age; gender; BMI; blood-group SARS-CoV-2; vaccine; BNT162b2; antibody; serology; kinetic; age; gender; BMI; blood-group
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MDPI and ACS Style

Bayart, J.-L.; Morimont, L.; Closset, M.; Wieërs, G.; Roy, T.; Gerin, V.; Elsen, M.; Eucher, C.; Van Eeckhoudt, S.; Ausselet, N.; David, C.; Mullier, F.; Dogné, J.-M.; Favresse, J.; Douxfils, J. Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2. Microorganisms 2021, 9, 1340. https://doi.org/10.3390/microorganisms9061340

AMA Style

Bayart J-L, Morimont L, Closset M, Wieërs G, Roy T, Gerin V, Elsen M, Eucher C, Van Eeckhoudt S, Ausselet N, David C, Mullier F, Dogné J-M, Favresse J, Douxfils J. Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2. Microorganisms. 2021; 9(6):1340. https://doi.org/10.3390/microorganisms9061340

Chicago/Turabian Style

Bayart, Jean-Louis, Laure Morimont, Mélanie Closset, Grégoire Wieërs, Tatiana Roy, Vincent Gerin, Marc Elsen, Christine Eucher, Sandrine Van Eeckhoudt, Nathalie Ausselet, Clara David, François Mullier, Jean-Michel Dogné, Julien Favresse, and Jonathan Douxfils. 2021. "Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2" Microorganisms 9, no. 6: 1340. https://doi.org/10.3390/microorganisms9061340

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