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From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models

Laboratoire Microorganismes: Génome et Environnement, Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, France
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Academic Editors: Aida Duarte and Cátia Caneiras
Microorganisms 2021, 9(6), 1282; https://doi.org/10.3390/microorganisms9061282
Received: 28 May 2021 / Revised: 8 June 2021 / Accepted: 9 June 2021 / Published: 12 June 2021
(This article belongs to the Special Issue Virulence and Resistance of Klebsiella pneumoniae)
Klebsiella pneumoniae is a Gram-negative pathogen responsible for community-acquired and nosocomial infections. The strains of this species belong to the opportunistic group, which is comprised of the multidrug-resistant strains, or the hypervirulent group, depending on their accessory genome, which determines bacterial pathogenicity and the host immune response. The aim of this survey is to present an overview of the murine models mimicking K. pneumoniae infectious processes (i.e., gastrointestinal colonization, urinary, pulmonary, and systemic infections), and the bacterial functions deployed to colonize and disseminate into the host. These in vivo approaches are pivotal to develop new therapeutics to limit K. pneumoniae infections via a modulation of the immune responses and/or microbiota. View Full-Text
Keywords: Klebsiella pneumoniae; in vivo murine models; colonization and virulence factors; new therapeutics Klebsiella pneumoniae; in vivo murine models; colonization and virulence factors; new therapeutics
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MDPI and ACS Style

Joseph, L.; Merciecca, T.; Forestier, C.; Balestrino, D.; Miquel, S. From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models. Microorganisms 2021, 9, 1282. https://doi.org/10.3390/microorganisms9061282

AMA Style

Joseph L, Merciecca T, Forestier C, Balestrino D, Miquel S. From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models. Microorganisms. 2021; 9(6):1282. https://doi.org/10.3390/microorganisms9061282

Chicago/Turabian Style

Joseph, Laura, Thomas Merciecca, Christiane Forestier, Damien Balestrino, and Sylvie Miquel. 2021. "From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models" Microorganisms 9, no. 6: 1282. https://doi.org/10.3390/microorganisms9061282

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