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Volume 9
Issue 6
10.3390/microorganisms9061264
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Communication

Epidemiological Significance of SARS-CoV-2 RNA Dynamic in Naso-Pharyngeal Swabs

by
Paolo Calistri
,
Maria Luisa Danzetta
,
Laura Amato
,
Francesca Cito
,
Alessandra Di Giuseppe
*,
Valentina Zenobio
,
Daniela Morelli
,
Ilaria Puglia
,
Marialuigia Caporale
,
Silvia Scialabba
,
Giovanni Savini
,
Giacomo Migliorati
,
Nicola D’Alterio
and
Alessio Lorusso
Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise G. Caporale, 64100 Teramo, Italy
*
Author to whom correspondence should be addressed.
Microorganisms 2021, 9(6), 1264; https://doi.org/10.3390/microorganisms9061264
Submission received: 15 March 2021 / Revised: 23 April 2021 / Accepted: 7 June 2021 / Published: 10 June 2021
(This article belongs to the Special Issue SARS-CoV-2: Epidemiology and Pathogenesis)
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Abstract

From 16 March to 15 December 2020, 132,357 naso-pharyngeal/oropharyngeal swabs were collected in the province of Teramo, Abruzzo Region, Italy, and tested for the presence of SARS-CoV-2 genomic RNA by a commercially available molecular assay. A total of 12,880 swabs resulted positive. For 8212 positive patients (4.150 women and 4.062 men) the median age was statistically different between women (median: 49.55 ± 23.9 of SD) and men (median: 48.35 ± 23.5 of SD) while no differences were found in the comparison between the cycle threshold for the N protein-encoding gene (CT N) median values and gender. Differences were observed in the CT N gene median values of swabs collected from March to September as well as in the pairwise comparison between September and October and between November and December. The CT N gene median values observed in specific periods characterizing the SARS-CoV-2 epidemic in 2020 were also compared with the incidence of COVID-19 cases; a strong inverse correlation was highlighted (Pearson correlation coefficient = −0.978). Our findings confirm the usefulness of the CT N values as an indirect detection parameter to monitor viral loads in the population.
Keywords: SARS-CoV-2; cycle threshold; Abruzzo; COVID-19; naso-pharyngeal swab; viral circulation SARS-CoV-2; cycle threshold; Abruzzo; COVID-19; naso-pharyngeal swab; viral circulation

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MDPI and ACS Style

Calistri, P.; Danzetta, M.L.; Amato, L.; Cito, F.; Di Giuseppe, A.; Zenobio, V.; Morelli, D.; Puglia, I.; Caporale, M.; Scialabba, S.; et al. Epidemiological Significance of SARS-CoV-2 RNA Dynamic in Naso-Pharyngeal Swabs. Microorganisms 2021, 9, 1264. https://doi.org/10.3390/microorganisms9061264

AMA Style

Calistri P, Danzetta ML, Amato L, Cito F, Di Giuseppe A, Zenobio V, Morelli D, Puglia I, Caporale M, Scialabba S, et al. Epidemiological Significance of SARS-CoV-2 RNA Dynamic in Naso-Pharyngeal Swabs. Microorganisms. 2021; 9(6):1264. https://doi.org/10.3390/microorganisms9061264

Chicago/Turabian Style

Calistri, Paolo, Maria Luisa Danzetta, Laura Amato, Francesca Cito, Alessandra Di Giuseppe, Valentina Zenobio, Daniela Morelli, Ilaria Puglia, Marialuigia Caporale, Silvia Scialabba, and et al. 2021. "Epidemiological Significance of SARS-CoV-2 RNA Dynamic in Naso-Pharyngeal Swabs" Microorganisms 9, no. 6: 1264. https://doi.org/10.3390/microorganisms9061264

APA Style

Calistri, P., Danzetta, M. L., Amato, L., Cito, F., Di Giuseppe, A., Zenobio, V., Morelli, D., Puglia, I., Caporale, M., Scialabba, S., Savini, G., Migliorati, G., D’Alterio, N., & Lorusso, A. (2021). Epidemiological Significance of SARS-CoV-2 RNA Dynamic in Naso-Pharyngeal Swabs. Microorganisms, 9(6), 1264. https://doi.org/10.3390/microorganisms9061264

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