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Article

SARS-CoV-2 IgG Antibodies Seroprevalence and Sera Neutralizing Activity in MEXICO: A National Cross-Sectional Study during 2020

1
División de Laboratorios de Vigilancia e Investigación Epidemiológica, IMSS, 07760 Ciudad de México, Mexico
2
Coordinación de Control Técnico e Insumos, IMSS, 07760 Ciudad de México, Mexico
3
Estancia Posdoctoral (CONACyT), Laboratorio Central de Epidemiología, IMSS, 02990 Ciudad de México, Mexico
4
Escuela Nacional de Ciencias Biológicas, IPN, 11340 Ciudad de México, Mexico
5
Unidad de Investigación Médica en Inmunoquímica, UMAE Hospital de Especialidades, Centro Médico Nacional “Siglo XXI”, IMSS, 06720 Ciudad de México, Mexico
6
Laboratorio de Genómica, Departamento de Genética y Genómica Humana, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes”, 11000 Ciudad de México, Mexico
7
Laboratorio Central de Epidemiología, IMSS, 02990 Ciudad de México, Mexico
8
Dirección de Prestaciones Médicas, IMSS, 06600 Ciudad de México, Mexico
9
Coordinación de Investigación en Salud, 06720 Ciudad de México, Mexico
10
Instituto de Salud para el Bienestar, 01020 Ciudad de México, Mexico
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Paolo Calistri
Microorganisms 2021, 9(4), 850; https://doi.org/10.3390/microorganisms9040850
Received: 28 March 2021 / Revised: 8 April 2021 / Accepted: 9 April 2021 / Published: 15 April 2021
(This article belongs to the Special Issue SARS-CoV-2: Epidemiology and Pathogenesis)
Until recently, the incidence of COVID-19 was primarily estimated using molecular diagnostic methods. However, the number of cases is vastly underreported using these methods. Seroprevalence studies estimate cumulative infection incidences and allow monitoring of transmission dynamics, and the presence of neutralizing antibodies in the population. In February 2020, the Mexican Social Security Institute began conducting anonymous unrelated sampling of residual sera from specimens across the country, excluding patients with fever within the previous two weeks and/or patients with an acute respiratory infection. Sampling was carried out weekly and began 17 days before Mexico’s first officially confirmed case. The 24,273 sera obtained were analyzed by chemiluminescent-linked immunosorbent assay (CLIA) IgG S1/S2 and, later, positive cases using this technique were also analyzed to determine the rate of neutralization using the enzyme-linked immunosorbent assay (ELISA). We identified 40 CLIA IgG positive cases before the first official report of SARS-CoV-2 infection in Mexico. The national seroprevalence was 3.5% in February and 33.5% in December. Neutralizing activity among IgG positives patients during overall study period was 86.1%. The extent of the SARS-CoV-2 infection in Mexico is 21 times higher than that reported by molecular techniques. Although the general population is still far from achieving herd immunity, epidemiological indicators should be re-estimated based on serological studies of this type. View Full-Text
Keywords: COVID-19; herd immunity; serology; antibody neutralization; clinical laboratory; blood bank; CLIA; ELISA COVID-19; herd immunity; serology; antibody neutralization; clinical laboratory; blood bank; CLIA; ELISA
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MDPI and ACS Style

Muñoz-Medina, J.E.; Grajales-Muñiz, C.; Salas-Lais, A.G.; Fernandes-Matano, L.; López-Macías, C.; Monroy-Muñoz, I.E.; Santos Coy-Arechavaleta, A.; Palomec-Nava, I.D.; Duque-Molina, C.; Madera-Sandoval, R.L.; Rivero-Arredondo, V.; González-Ibarra, J.; Alvarado-Yaah, J.E.; Rojas-Mendoza, T.; Santacruz-Tinoco, C.E.; González-Bonilla, C.R.; Borja-Aburto, V.H. SARS-CoV-2 IgG Antibodies Seroprevalence and Sera Neutralizing Activity in MEXICO: A National Cross-Sectional Study during 2020. Microorganisms 2021, 9, 850. https://doi.org/10.3390/microorganisms9040850

AMA Style

Muñoz-Medina JE, Grajales-Muñiz C, Salas-Lais AG, Fernandes-Matano L, López-Macías C, Monroy-Muñoz IE, Santos Coy-Arechavaleta A, Palomec-Nava ID, Duque-Molina C, Madera-Sandoval RL, Rivero-Arredondo V, González-Ibarra J, Alvarado-Yaah JE, Rojas-Mendoza T, Santacruz-Tinoco CE, González-Bonilla CR, Borja-Aburto VH. SARS-CoV-2 IgG Antibodies Seroprevalence and Sera Neutralizing Activity in MEXICO: A National Cross-Sectional Study during 2020. Microorganisms. 2021; 9(4):850. https://doi.org/10.3390/microorganisms9040850

Chicago/Turabian Style

Muñoz-Medina, José Esteban, Concepción Grajales-Muñiz, Angel Gustavo Salas-Lais, Larissa Fernandes-Matano, Constantino López-Macías, Irma Eloísa Monroy-Muñoz, Andrea Santos Coy-Arechavaleta, Iliana Donají Palomec-Nava, Célida Duque-Molina, Ruth Lizzeth Madera-Sandoval, Vanessa Rivero-Arredondo, Joaquín González-Ibarra, Julio Elías Alvarado-Yaah, Teresita Rojas-Mendoza, Clara Esperanza Santacruz-Tinoco, Cesar Raúl González-Bonilla, and Víctor Hugo Borja-Aburto. 2021. "SARS-CoV-2 IgG Antibodies Seroprevalence and Sera Neutralizing Activity in MEXICO: A National Cross-Sectional Study during 2020" Microorganisms 9, no. 4: 850. https://doi.org/10.3390/microorganisms9040850

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