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Article

Morinagadepsin, a Depsipeptide from the Fungus Morinagamyces vermicularis gen. et comb. nov.

1
Department Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
2
Institute of Microbiology, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany
3
Mycology Unit, Medical School and IISPV, Universitat Rovira i Virgili, C/ Sant Llorenç 21, 43201 Reus, Tarragona, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Giovanni Di Bonaventura
Microorganisms 2021, 9(6), 1191; https://doi.org/10.3390/microorganisms9061191
Received: 23 April 2021 / Revised: 25 May 2021 / Accepted: 27 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Hotspots of Fungal Diversity)
The new genus Morinagamyces is introduced herein to accommodate the fungus Apiosordaria vermicularis as inferred from a phylogenetic study based on sequences of the internal transcribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and partial fragments of ribosomal polymerase II subunit 2 (rpb2) and β-tubulin (tub2) genes. Morinagamyces vermicularis was analyzed for the production of secondary metabolites, resulting in the isolation of a new depsipeptide named morinagadepsin (1), and the already known chaetone B (3). While the planar structure of 1 was elucidated by extensive 1D- and 2D-NMR analysis and high-resolution mass spectrometry, the absolute configuration of the building blocks Ala, Val, and Leu was determined as -l by Marfey’s method. The configuration of the 3-hydroxy-2-methyldecanyl unit was assigned as 22R,23R by J-based configuration analysis and Mosher’s method after partial hydrolysis of the morinagadepsin to the linear derivative compound 2. Compound 1 showed cytotoxic activity against the mammalian cell lines KB3.1 and L929, but no antimicrobial activity against the fungi and bacteria tested was observed, while 2 was inactive. Compound 3 was weakly cytotoxic against the cell line L929, but did not show any antimicrobial activity. View Full-Text
Keywords: cytotoxicity; depsipeptide; Morinagamyces; morinagadepsin; Schizotheciaceae; secondary metabolites; Sordariales cytotoxicity; depsipeptide; Morinagamyces; morinagadepsin; Schizotheciaceae; secondary metabolites; Sordariales
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MDPI and ACS Style

Harms, K.; Surup, F.; Stadler, M.; Stchigel, A.M.; Marin-Felix, Y. Morinagadepsin, a Depsipeptide from the Fungus Morinagamyces vermicularis gen. et comb. nov. Microorganisms 2021, 9, 1191. https://doi.org/10.3390/microorganisms9061191

AMA Style

Harms K, Surup F, Stadler M, Stchigel AM, Marin-Felix Y. Morinagadepsin, a Depsipeptide from the Fungus Morinagamyces vermicularis gen. et comb. nov. Microorganisms. 2021; 9(6):1191. https://doi.org/10.3390/microorganisms9061191

Chicago/Turabian Style

Harms, Karen, Frank Surup, Marc Stadler, Alberto M. Stchigel, and Yasmina Marin-Felix. 2021. "Morinagadepsin, a Depsipeptide from the Fungus Morinagamyces vermicularis gen. et comb. nov." Microorganisms 9, no. 6: 1191. https://doi.org/10.3390/microorganisms9061191

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