The new genus
Morinagamyces is introduced herein to accommodate the fungus
Apiosordaria vermicularis as inferred from a phylogenetic study based on sequences of the internal transcribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and partial fragments of ribosomal polymerase II subunit
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The new genus
Morinagamyces is introduced herein to accommodate the fungus
Apiosordaria vermicularis as inferred from a phylogenetic study based on sequences of the internal transcribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and partial fragments of ribosomal polymerase II subunit 2 (
rpb2) and β-tubulin (
tub2) genes.
Morinagamyces vermicularis was analyzed for the production of secondary metabolites, resulting in the isolation of a new depsipeptide named morinagadepsin (
1), and the already known chaetone B (
3). While the planar structure of
1 was elucidated by extensive 1D- and 2D-NMR analysis and high-resolution mass spectrometry, the absolute configuration of the building blocks Ala, Val, and Leu was determined as -
l by Marfey’s method. The configuration of the 3-hydroxy-2-methyldecanyl unit was assigned as 22
R,23
R by
J-based configuration analysis and Mosher’s method after partial hydrolysis of the morinagadepsin to the linear derivative compound
2. Compound
1 showed cytotoxic activity against the mammalian cell lines KB3.1 and L929, but no antimicrobial activity against the fungi and bacteria tested was observed, while
2 was inactive. Compound
3 was weakly cytotoxic against the cell line L929, but did not show any antimicrobial activity.
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