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Article

Exploring the Chemical Space of Macro- and Micro-Algae Using Comparative Metabolomics

1
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK
2
Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt
3
Scottish Association for Marine Science, Scottish Marine Institute, Oban PA37 1QA, UK
4
Culture Collection of Algae and Protozoa (CCAP), Scottish Marine Institute, Oban PA37 1QA, UK
5
Axxam SpA, Openzone, Bresso, 20091 Milan, Italy
*
Author to whom correspondence should be addressed.
Current address: GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany.
Current address: Molecular Discovery Group, Computational and Analytical Science, Rothamsted Research, Harpenden AL5 2JQ, UK.
Academic Editor: Spiros N. Agathos
Microorganisms 2021, 9(2), 311; https://doi.org/10.3390/microorganisms9020311
Received: 17 December 2020 / Revised: 26 January 2021 / Accepted: 30 January 2021 / Published: 3 February 2021
(This article belongs to the Special Issue Natural Products from Microalgae and Cyanobacteria)
With more than 156,000 described species, eukaryotic algae (both macro- and micro-algae) are a rich source of biological diversity, however their chemical diversity remains largely unexplored. Specialised metabolites with promising biological activities have been widely reported for seaweeds, and more recently extracts from microalgae have exhibited activity in anticancer, antimicrobial, and antioxidant screens. However, we are still missing critical information on the distinction of chemical profiles between macro- and microalgae, as well as the chemical space these metabolites cover. This study has used an untargeted comparative metabolomics approach to explore the chemical diversity of seven seaweeds and 36 microalgal strains. A total of 1390 liquid chromatography-mass spectrometry (LC-MS) features were detected, representing small organic algal metabolites, with no overlap between the seaweeds and microalgae. An in-depth analysis of four Dunaliella tertiolecta strains shows that environmental factors may play a larger role than phylogeny when classifying their metabolomic profiles. View Full-Text
Keywords: microalgae; comparative metabolomics; biotechnology; bioactivity; mass spectrometry; microalgal metabolites microalgae; comparative metabolomics; biotechnology; bioactivity; mass spectrometry; microalgal metabolites
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MDPI and ACS Style

Hughes, A.H.; Magot, F.; Tawfike, A.F.; Rad-Menéndez, C.; Thomas, N.; Young, L.C.; Stucchi, L.; Carettoni, D.; Stanley, M.S.; Edrada-Ebel, R.; Duncan, K.R. Exploring the Chemical Space of Macro- and Micro-Algae Using Comparative Metabolomics. Microorganisms 2021, 9, 311. https://doi.org/10.3390/microorganisms9020311

AMA Style

Hughes AH, Magot F, Tawfike AF, Rad-Menéndez C, Thomas N, Young LC, Stucchi L, Carettoni D, Stanley MS, Edrada-Ebel R, Duncan KR. Exploring the Chemical Space of Macro- and Micro-Algae Using Comparative Metabolomics. Microorganisms. 2021; 9(2):311. https://doi.org/10.3390/microorganisms9020311

Chicago/Turabian Style

Hughes, Alison H., Florent Magot, Ahmed F. Tawfike, Cecilia Rad-Menéndez, Naomi Thomas, Louise C. Young, Laura Stucchi, Daniele Carettoni, Michele S. Stanley, RuAngelie Edrada-Ebel, and Katherine R. Duncan 2021. "Exploring the Chemical Space of Macro- and Micro-Algae Using Comparative Metabolomics" Microorganisms 9, no. 2: 311. https://doi.org/10.3390/microorganisms9020311

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