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Volume 9
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10.3390/microorganisms9122432
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Article

High-Fructose Diet Alters Intestinal Microbial Profile and Correlates with Early Tumorigenesis in a Mouse Model of Barrett’s Esophagus

by
Andrea Proaño-Vasco
1,2,†,
Theresa Baumeister
1,2,†,
Amira Metwaly
3,
Sandra Reitmeier
3,4,
Karin Kleigrewe
5,
Chen Meng
5,
Michael Gigl
5,
Thomas Engleitner
6,
Rupert Öllinger
6,
Roland Rad
6,
Katja Steiger
7,
Akanksha Anand
1,
Julia Strangmann
2,
Robert Thimme
2,
Roland M. Schmid
1,
Timothy C. Wang
8 and
Michael Quante
1,2,*
1
Department of Internal Medicine II, Klinikum Rechts der Isar, Technical University Munich (TUM), 81675 München, Germany
2
Department of Internal Medicine II, Universitätsklinik Freiburg, Universität Freiburg, 79106 Freiburg, Germany
3
Chair of Nutrition and Immunology, Technical University Munich (TUM), 85354 München, Germany
4
ZIEL—Institute for Food & Health, Core Facility Mikrobiom, Technical University of Munich (TUM), 85354 München, Germany
5
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich (TUM), 85354 München, Germany
6
Institute of Molecular Oncology and Functional Genomics, Klinikum Rechts der Isar, Technical University Munich (TUM), 81675 München, Germany
7
Department of Pathology, Klinikum Rechts der Isar, Technical University Munich (TUM), 81675 München, Germany
8
Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2021, 9(12), 2432; https://doi.org/10.3390/microorganisms9122432
Submission received: 31 October 2021 / Revised: 16 November 2021 / Accepted: 18 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue Bacteria and Esophageal Cancer)
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Abstract

Esophageal adenocarcinoma (EAC) is mostly prevalent in industrialized countries and has been associated with obesity, commonly linked with a diet rich in fat and refined sugars containing high fructose concentrations. In meta-organisms, dietary components are digested and metabolized by the host and its gut microbiota. Fructose has been shown to induce proliferation and cell growth in pancreas and colon cancer cell lines and also alter the gut microbiota. In a previous study with the L2-IL-1B mouse model, we showed that a high-fat diet (HFD) accelerated EAC progression from its precursor lesion Barrett’s esophagus (BE) through changes in the gut microbiota. Aiming to investigate whether a high-fructose diet (HFrD) also alters the gut microbiota and favors EAC carcinogenesis, we assessed the effects of HFrD on the phenotype and intestinal microbial communities of L2-IL1B mice. Results showed a moderate acceleration in histologic disease progression, a mild effect on the systemic inflammatory response, metabolic changes in the host, and a shift in the composition, metabolism, and functionality of intestinal microbial communities. We conclude that HFrD alters the overall balance of the gut microbiota and induces an acceleration in EAC progression in a less pronounced manner than HFD.
Keywords: Barrett’s esophagus; esophageal adenocarcinoma; IL-1B-mouse model; Western diet; fructose; microbiota; metabolism Barrett’s esophagus; esophageal adenocarcinoma; IL-1B-mouse model; Western diet; fructose; microbiota; metabolism

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MDPI and ACS Style

Proaño-Vasco, A.; Baumeister, T.; Metwaly, A.; Reitmeier, S.; Kleigrewe, K.; Meng, C.; Gigl, M.; Engleitner, T.; Öllinger, R.; Rad, R.; et al. High-Fructose Diet Alters Intestinal Microbial Profile and Correlates with Early Tumorigenesis in a Mouse Model of Barrett’s Esophagus. Microorganisms 2021, 9, 2432. https://doi.org/10.3390/microorganisms9122432

AMA Style

Proaño-Vasco A, Baumeister T, Metwaly A, Reitmeier S, Kleigrewe K, Meng C, Gigl M, Engleitner T, Öllinger R, Rad R, et al. High-Fructose Diet Alters Intestinal Microbial Profile and Correlates with Early Tumorigenesis in a Mouse Model of Barrett’s Esophagus. Microorganisms. 2021; 9(12):2432. https://doi.org/10.3390/microorganisms9122432

Chicago/Turabian Style

Proaño-Vasco, Andrea, Theresa Baumeister, Amira Metwaly, Sandra Reitmeier, Karin Kleigrewe, Chen Meng, Michael Gigl, Thomas Engleitner, Rupert Öllinger, Roland Rad, and et al. 2021. "High-Fructose Diet Alters Intestinal Microbial Profile and Correlates with Early Tumorigenesis in a Mouse Model of Barrett’s Esophagus" Microorganisms 9, no. 12: 2432. https://doi.org/10.3390/microorganisms9122432

APA Style

Proaño-Vasco, A., Baumeister, T., Metwaly, A., Reitmeier, S., Kleigrewe, K., Meng, C., Gigl, M., Engleitner, T., Öllinger, R., Rad, R., Steiger, K., Anand, A., Strangmann, J., Thimme, R., Schmid, R. M., Wang, T. C., & Quante, M. (2021). High-Fructose Diet Alters Intestinal Microbial Profile and Correlates with Early Tumorigenesis in a Mouse Model of Barrett’s Esophagus. Microorganisms, 9(12), 2432. https://doi.org/10.3390/microorganisms9122432

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