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Microorganisms
Volume 9
Issue 11
10.3390/microorganisms9112263
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Article

Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR

by
Elodie Calvez
1,*,
Phaithong Bounmany
1,
Charlotte Balière
2,
Somphavanh Somlor
1,
Souksakhone Viengphouthong
1,
Thonglakhone Xaybounsou
1,
Sitsana Keosenhom
1,
Kitphithak Fangkham
1,3,
Paul T. Brey
4,
Valérie Caro
2,
Vincent Lacoste
1 and
Marc Grandadam
1,†
1
Arbovirus and Emerging Viral Diseases Laboratory, Institut Pasteur du Laos, Vientiane 01030, Laos
2
Environment and Infectious Risks Unit, Institut Pasteur, 75015 Paris, France
3
Lao Army Institute for Preventive Medicine, Vientiane 01030, Laos
4
Medical Entomology and Vector Borne Disease Unit, Institut Pasteur du Laos, Vientiane 01030, Laos
*
Author to whom correspondence should be addressed.
†
Current affiliation: Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
Microorganisms 2021, 9(11), 2263; https://doi.org/10.3390/microorganisms9112263
Submission received: 30 September 2021 / Revised: 21 October 2021 / Accepted: 25 October 2021 / Published: 30 October 2021
(This article belongs to the Special Issue Arboviruses: Diagnostic, Phylogeny and Interactions)
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Abstract

Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 still co-circulated in the country over this period. Here, we summarize epidemiological and molecular data of DENV-1 between 2016 and 2020 in the Lao PDR. Our data highlight the continuous circulation of DENV-1 in the country at levels ranging from 16% to 22% among serotyping tests. In addition, the phylogenetic analysis has revealed the circulation of DENV-1 genotype I at least since 2008 with a co-circulation of different clusters. Sequence data support independent DENV-1 introductions in the Lao PDR correlated with an active circulation of this serotype at the regional level in Southeast Asia. The maintenance of DENV-1 circulation over the last ten years supports a low level of immunity against this serotype within the Lao population. Thereby, the risk of a DENV-1 epidemic cannot be ruled out in the future, and this emphasizes the importance of maintaining an integrated surveillance approach to prevent major outbreaks.
Keywords: dengue; DENV-1; epidemiology; phylogeny; Lao PDR dengue; DENV-1; epidemiology; phylogeny; Lao PDR

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MDPI and ACS Style

Calvez, E.; Bounmany, P.; Balière, C.; Somlor, S.; Viengphouthong, S.; Xaybounsou, T.; Keosenhom, S.; Fangkham, K.; Brey, P.T.; Caro, V.; et al. Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR. Microorganisms 2021, 9, 2263. https://doi.org/10.3390/microorganisms9112263

AMA Style

Calvez E, Bounmany P, Balière C, Somlor S, Viengphouthong S, Xaybounsou T, Keosenhom S, Fangkham K, Brey PT, Caro V, et al. Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR. Microorganisms. 2021; 9(11):2263. https://doi.org/10.3390/microorganisms9112263

Chicago/Turabian Style

Calvez, Elodie, Phaithong Bounmany, Charlotte Balière, Somphavanh Somlor, Souksakhone Viengphouthong, Thonglakhone Xaybounsou, Sitsana Keosenhom, Kitphithak Fangkham, Paul T. Brey, Valérie Caro, and et al. 2021. "Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR" Microorganisms 9, no. 11: 2263. https://doi.org/10.3390/microorganisms9112263

APA Style

Calvez, E., Bounmany, P., Balière, C., Somlor, S., Viengphouthong, S., Xaybounsou, T., Keosenhom, S., Fangkham, K., Brey, P. T., Caro, V., Lacoste, V., & Grandadam, M. (2021). Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR. Microorganisms, 9(11), 2263. https://doi.org/10.3390/microorganisms9112263

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