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Microorganisms
Volume 8
Issue 9
10.3390/microorganisms8091424
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Review

TRIM Proteins and Their Roles in the Influenza Virus Life Cycle

by
Hye-Ra Lee
1,
Myoung Kyu Lee
2,
Chan Woo Kim
1 and
Meehyein Kim
2,*
1
Department of Biotechnology and Bioinformatics, College of Science and Technology, Korea University, 2511 Sejong-ro, Sejong 30019, Korea
2
Infectious Diseases Therapeutics Research Center, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, Korea
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(9), 1424; https://doi.org/10.3390/microorganisms8091424
Submission received: 17 July 2020 / Revised: 12 September 2020 / Accepted: 15 September 2020 / Published: 16 September 2020
(This article belongs to the Special Issue The Biology of Influenza Viruses)
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Abstract

The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects of cellular physiology. Especially tripartite motif (TRIM) proteins, well-known E3 ubiquitin ligases, emerge as having critical roles in several antiviral signaling pathways against varying viral infections. Here we highlight recent advances in the study of antiviral roles of TRIM proteins toward influenza virus infection in terms of the modulation of pathogen recognition receptor (PRR)-mediated innate immune sensing, direct obstruction of influenza viral propagation, and participation in virus-induced autophagy.
Keywords: influenza virus; ubiquitination; antiviral immunity; TRIM family influenza virus; ubiquitination; antiviral immunity; TRIM family

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MDPI and ACS Style

Lee, H.-R.; Lee, M.K.; Kim, C.W.; Kim, M. TRIM Proteins and Their Roles in the Influenza Virus Life Cycle. Microorganisms 2020, 8, 1424. https://doi.org/10.3390/microorganisms8091424

AMA Style

Lee H-R, Lee MK, Kim CW, Kim M. TRIM Proteins and Their Roles in the Influenza Virus Life Cycle. Microorganisms. 2020; 8(9):1424. https://doi.org/10.3390/microorganisms8091424

Chicago/Turabian Style

Lee, Hye-Ra, Myoung Kyu Lee, Chan Woo Kim, and Meehyein Kim. 2020. "TRIM Proteins and Their Roles in the Influenza Virus Life Cycle" Microorganisms 8, no. 9: 1424. https://doi.org/10.3390/microorganisms8091424

APA Style

Lee, H.-R., Lee, M. K., Kim, C. W., & Kim, M. (2020). TRIM Proteins and Their Roles in the Influenza Virus Life Cycle. Microorganisms, 8(9), 1424. https://doi.org/10.3390/microorganisms8091424

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