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Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study

1
Multidisciplinary Sepsis Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
2
Intensive Care Unit, Son Llatzer University Hospital, Balearic Islands, 07198 Palma de Mallorca, Spain
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Internal Medicine Unit, Son Llatzer University Hospital, Balearic Islands, 07120 Palma de Mallorca, Spain
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Cardiopulmonary Pathology of the Critically Ill Patient Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
5
Vascular and Metabolic Pathologies Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
*
Authors to whom correspondence should be addressed.
Microorganisms 2020, 8(8), 1106; https://doi.org/10.3390/microorganisms8081106
Received: 25 May 2020 / Revised: 13 July 2020 / Accepted: 21 July 2020 / Published: 24 July 2020
(This article belongs to the Section Medical Microbiology)
There is limited information available describing the clinical and epidemiological features of Spanish patients requiring hospitalization for coronavirus disease 2019 (COVID-19). In this observational study, we aimed to describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior to hospitalization. Forty-eight patients (27 non-ICU and 21 ICU) with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were analyzed (mean age, 66 years, [range, 33–88 years]; 67% males). There were no differences in age or sex among groups. Initial symptoms included fever (100%), coughing (85%), dyspnea (76%), diarrhea (42%) and asthenia (21%). ICU patients had a higher prevalence of dyspnea compared to non-ICU patients (95% vs. 61%, p = 0.022). ICU-patients had lymphopenia as well as hypoalbuminemia. Lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < 0.001). Lower albumin levels were associated with poor prognosis measured as longer hospital length (r = −0.472, p < 0.001) and mortality (r = −0.424, p = 0.003). As of 28 April 2020, 10 patients (8 ICU and 2 non-ICU) have died (21% mortality), and while 100% of the non-ICU patients have been discharged, 33% of the ICU patients still remained hospitalized (5 in ICU and 2 had been transferred to ward). Critically ill patients with COVID-19 present lymphopenia, hypoalbuminemia and high levels of inflammation. View Full-Text
Keywords: COVID-19; albumin; inflammation COVID-19; albumin; inflammation
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MDPI and ACS Style

de la Rica, R.; Borges, M.; Aranda, M.; del Castillo, A.; Socias, A.; Payeras, A.; Rialp, G.; Socias, L.; Masmiquel, L.; Gonzalez-Freire, M. Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study. Microorganisms 2020, 8, 1106. https://doi.org/10.3390/microorganisms8081106

AMA Style

de la Rica R, Borges M, Aranda M, del Castillo A, Socias A, Payeras A, Rialp G, Socias L, Masmiquel L, Gonzalez-Freire M. Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study. Microorganisms. 2020; 8(8):1106. https://doi.org/10.3390/microorganisms8081106

Chicago/Turabian Style

de la Rica, Roberto; Borges, Marcio; Aranda, Maria; del Castillo, Alberto; Socias, Antonia; Payeras, Antoni; Rialp, Gemma; Socias, Lorenzo; Masmiquel, Lluis; Gonzalez-Freire, Marta. 2020. "Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study" Microorganisms 8, no. 8: 1106. https://doi.org/10.3390/microorganisms8081106

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