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Open AccessArticle

Staphylococcus saccharolyticus: An Overlooked Human Skin Colonizer

1
Beiersdorf AG, Research & Development, Front End Innovation, 20245 Hamburg, Germany
2
Department of Microbiology and Biotechnology, University of Hamburg, 22609 Hamburg, Germany
3
Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark
4
Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, University of Göttingen, 37073 Göttingen, Germany
5
Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
6
Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, S-701 82 Örebro, Sweden
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(8), 1105; https://doi.org/10.3390/microorganisms8081105
Received: 7 July 2020 / Revised: 19 July 2020 / Accepted: 21 July 2020 / Published: 23 July 2020
(This article belongs to the Special Issue Human Skin Microbiota)
Coagulase-negative staphylococcal species constitute an important part of the human skin microbiota. In particular, facultative anaerobic species such as Staphylococcus epidermidis and Staphylococcus capitis can be found on the skin of virtually every human being. Here, we applied a culture-independent amplicon sequencing approach to identify staphylococcal species on the skin of healthy human individuals. While S. epidermidis and S. capitis were found as primary residents of back skin, surprisingly, the third most abundant member was Staphylococcus saccharolyticus, a relatively unstudied species. A search of skin metagenomic datasets detected sequences identical to the genome of S. saccharolyticus in diverse skin sites, including the back, forehead, and elbow pit. Although described as a slow-growing anaerobic species, a re-evaluation of its growth behavior showed that S. saccharolyticus can grow under oxic conditions, and, in particular, in a CO2-rich atmosphere. We argue here that S. saccharolyticus was largely overlooked in previous culture-dependent and -independent studies, due to its requirement for fastidious growth conditions and the lack of reference genome sequences, respectively. Future studies are needed to unravel the microbiology and host-interacting properties of S. saccharolyticus and its role as a prevalent skin colonizer. View Full-Text
Keywords: Staphylococcus saccharolyticus; coagulase-negative staphylococci; skin microbiota; skin microbiome; amplicon next generation sequencing Staphylococcus saccharolyticus; coagulase-negative staphylococci; skin microbiota; skin microbiome; amplicon next generation sequencing
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MDPI and ACS Style

Ahle, C.M.; Stødkilde, K.; Afshar, M.; Poehlein, A.; Ogilvie, L.A.; Söderquist, B.; Hüpeden, J.; Brüggemann, H. Staphylococcus saccharolyticus: An Overlooked Human Skin Colonizer. Microorganisms 2020, 8, 1105. https://doi.org/10.3390/microorganisms8081105

AMA Style

Ahle CM, Stødkilde K, Afshar M, Poehlein A, Ogilvie LA, Söderquist B, Hüpeden J, Brüggemann H. Staphylococcus saccharolyticus: An Overlooked Human Skin Colonizer. Microorganisms. 2020; 8(8):1105. https://doi.org/10.3390/microorganisms8081105

Chicago/Turabian Style

Ahle, Charlotte M.; Stødkilde, Kristian; Afshar, Mastaneh; Poehlein, Anja; Ogilvie, Lesley A.; Söderquist, Bo; Hüpeden, Jennifer; Brüggemann, Holger. 2020. "Staphylococcus saccharolyticus: An Overlooked Human Skin Colonizer" Microorganisms 8, no. 8: 1105. https://doi.org/10.3390/microorganisms8081105

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