Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

Fickers, Patrick; Cheng, Hairong; Sze Ki Lin, Carol

doi:10.3390/microorganisms8040574

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Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

by

Patrick Fickers

^1,*,

Hairong Cheng

² and

Carol Sze Ki Lin

³

¹

Microbial Process and Interactions, TERRA Teaching and Research Centre, University of Liege—Gembloux Agro-Bio Tech, 5030 Gembloux, Belgium

²

State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

³

School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong

^*

Author to whom correspondence should be addressed.

Microorganisms 2020, 8(4), 574; https://doi.org/10.3390/microorganisms8040574

Submission received: 9 March 2020 / Revised: 9 April 2020 / Accepted: 13 April 2020 / Published: 15 April 2020

(This article belongs to the Special Issue Yeast and Fungal Metabolites)

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Abstract

Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica.

Keywords: Yarrowia lipolytica; organic acids; polyols; sugar alcohols

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MDPI and ACS Style

Fickers, P.; Cheng, H.; Sze Ki Lin, C. Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We? Microorganisms 2020, 8, 574. https://doi.org/10.3390/microorganisms8040574

AMA Style

Fickers P, Cheng H, Sze Ki Lin C. Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We? Microorganisms. 2020; 8(4):574. https://doi.org/10.3390/microorganisms8040574

Chicago/Turabian Style

Fickers, Patrick, Hairong Cheng, and Carol Sze Ki Lin. 2020. "Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?" Microorganisms 8, no. 4: 574. https://doi.org/10.3390/microorganisms8040574

APA Style

Fickers, P., Cheng, H., & Sze Ki Lin, C. (2020). Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We? Microorganisms, 8(4), 574. https://doi.org/10.3390/microorganisms8040574

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

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