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Open AccessCommunication

OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador

1
Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador
2
Centro de Referencia Nacional de Resistencia a los Antimicrobianos, Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”, Quito 170403, Ecuador
3
Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170129, Ecuador
4
Centro de Investigación en Dinámica Celular, Instituto de Investigaciones Básicas y Aplicadas Universidad Autónoma del Estado de Morelos, Cuernavaca Morelos 62209, Mexico
5
Hospital de Especialidades Eugenio Espejo, Quito 170136, Ecuador
6
Ministerio de Salud Pública, Quito 170702, Ecuador
7
Universidad San Francisco de Quito, COCIBA, Instituto de Microbiología, Quito 170901, Ecuador
8
Administración Nacional de Laboratorios e Institutos de Salud ”Dr. Carlos G. Malbrán,” Buenos Aires 1281, Argentina
9
Pan American Health Organization/WHO, Washington, DC 20037, USA
10
Louisiana State University (LSU), Health Science Center, Shreveport, LA 71103, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Microorganisms 2020, 8(3), 435; https://doi.org/10.3390/microorganisms8030435
Received: 24 February 2020 / Revised: 10 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
(This article belongs to the Special Issue Infectious Diseases, New Approaches to Old Problems)
Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. Klebsiella pneumoniae is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. K. pneumoniae sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of Klebsiella pneumoniae (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases. View Full-Text
Keywords: Klebsiella pneumoniae; OXA-48 carbapenemase; carbapenemase-producing Enterobacterales Klebsiella pneumoniae; OXA-48 carbapenemase; carbapenemase-producing Enterobacterales
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Villacís, J.E.; Reyes, J.A.; Castelán-Sánchez, H.G.; Dávila-Ramos, S.; Lazo, M.A.; Wali, A.; Bodero, L.A.; Toapanta, Y.; Naranjo, C.; Montero, L.; Campos, J.; Galas, M.G.; Gestal, M.C. OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador. Microorganisms 2020, 8, 435.

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