Next Article in Journal / Special Issue
Application of an O-Linked Glycosylation System in Yersinia enterocolitica Serotype O:9 to Generate a New Candidate Vaccine against Brucella abortus
Previous Article in Journal
An Overview of Potential Oleaginous Microorganisms and Their Role in Biodiesel and Omega-3 Fatty Acid-Based Industries
Open AccessCommunication

OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador

Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador
Centro de Referencia Nacional de Resistencia a los Antimicrobianos, Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”, Quito 170403, Ecuador
Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170129, Ecuador
Centro de Investigación en Dinámica Celular, Instituto de Investigaciones Básicas y Aplicadas Universidad Autónoma del Estado de Morelos, Cuernavaca Morelos 62209, Mexico
Hospital de Especialidades Eugenio Espejo, Quito 170136, Ecuador
Ministerio de Salud Pública, Quito 170702, Ecuador
Universidad San Francisco de Quito, COCIBA, Instituto de Microbiología, Quito 170901, Ecuador
Administración Nacional de Laboratorios e Institutos de Salud ”Dr. Carlos G. Malbrán,” Buenos Aires 1281, Argentina
Pan American Health Organization/WHO, Washington, DC 20037, USA
Louisiana State University (LSU), Health Science Center, Shreveport, LA 71103, USA
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Microorganisms 2020, 8(3), 435;
Received: 24 February 2020 / Revised: 10 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
(This article belongs to the Special Issue Infectious Diseases, New Approaches to Old Problems)
Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. Klebsiella pneumoniae is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. K. pneumoniae sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of Klebsiella pneumoniae (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases. View Full-Text
Keywords: Klebsiella pneumoniae; OXA-48 carbapenemase; carbapenemase-producing Enterobacterales Klebsiella pneumoniae; OXA-48 carbapenemase; carbapenemase-producing Enterobacterales
Show Figures

Figure 1

MDPI and ACS Style

Villacís, J.E.; Reyes, J.A.; Castelán-Sánchez, H.G.; Dávila-Ramos, S.; Lazo, M.A.; Wali, A.; Bodero, L.A.; Toapanta, Y.; Naranjo, C.; Montero, L.; Campos, J.; Galas, M.G.; Gestal, M.C. OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador. Microorganisms 2020, 8, 435.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop