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Microorganisms
Volume 8
Issue 3
10.3390/microorganisms8030431
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Article

The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development

by
Giuseppina Campisciano
1,
Nicolò de Manzini
2,3,
Serena Delbue
4,
Carolina Cason
3,
Davide Cosola
2,
Giuseppe Basile
5,
Pasquale Ferrante
4,
Manola Comar
1,3,* and
Silvia Palmisano
2,3
1
SSD of Advanced Microbiology Diagnosis and Translational Research, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Via dell’Istria 65/1, 34137 Trieste, Italy
2
General Surgery Clinic, Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI), Strada di Fiume 447, 34149 Trieste, Italy
3
Department of Medical, Surgical and Health Sciences, Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI), Strada di Fiume 447, 34149 Trieste, Italy
4
Department of Biomedical, Surgical and Dental Sciences, Laboratory of Translational Research, Via Carlo Pascal 36, 20133 Milano, Italy
5
Clinical Institute San Siro, Via Monreale 18, 20148 Milano, Italy
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(3), 431; https://doi.org/10.3390/microorganisms8030431
Submission received: 9 February 2020 / Revised: 16 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
(This article belongs to the Special Issue Virus-Host Interaction: From Physiology to Pathology)
Versions Notes

Abstract

An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colonization by mucin degraders species, such as Hafnia alvei and Akkermansia muciniphila. In addition, the species Clostridium bolteae, a bacterium associated with insulin resistance, dyslipidemia, and inflammation, has been associated with the presence of oncogenic Human Polyomaviruses (HPyVs). Merkel cell Polyomavirus (MCPyV) and BK Polyomavirus (BKPyV) were the most frequently oncogenic viruses recovered in the gut of both obese and tumor patients. Considering the high seroprevalence of HPyVs in childhood, their association with specific bacterial species deserve to be further investigated. Data from the present study highlight the presence of a similar microbiome pattern in CRC and obese subjects, suggesting that obese microbiome may represent an opportunity for tumorigenic/driver bacteria and viruses to trigger cell transformation.
Keywords: microbiome; cancer pathogenesis; dysbiotic microbiota; obesity; gut microbiota microbiome; cancer pathogenesis; dysbiotic microbiota; obesity; gut microbiota

Share and Cite

MDPI and ACS Style

Campisciano, G.; de Manzini, N.; Delbue, S.; Cason, C.; Cosola, D.; Basile, G.; Ferrante, P.; Comar, M.; Palmisano, S. The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development. Microorganisms 2020, 8, 431. https://doi.org/10.3390/microorganisms8030431

AMA Style

Campisciano G, de Manzini N, Delbue S, Cason C, Cosola D, Basile G, Ferrante P, Comar M, Palmisano S. The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development. Microorganisms. 2020; 8(3):431. https://doi.org/10.3390/microorganisms8030431

Chicago/Turabian Style

Campisciano, Giuseppina, Nicolò de Manzini, Serena Delbue, Carolina Cason, Davide Cosola, Giuseppe Basile, Pasquale Ferrante, Manola Comar, and Silvia Palmisano. 2020. "The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development" Microorganisms 8, no. 3: 431. https://doi.org/10.3390/microorganisms8030431

APA Style

Campisciano, G., de Manzini, N., Delbue, S., Cason, C., Cosola, D., Basile, G., Ferrante, P., Comar, M., & Palmisano, S. (2020). The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development. Microorganisms, 8(3), 431. https://doi.org/10.3390/microorganisms8030431

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