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Antimicrobial Peptides: Virulence and Resistance Modulation in Gram-Negative Bacteria

Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Succ. Centre-ville, Montréal, QC H3C 3J7, Canada
Microorganisms 2020, 8(2), 280; https://doi.org/10.3390/microorganisms8020280
Received: 6 December 2019 / Revised: 17 February 2020 / Accepted: 17 February 2020 / Published: 19 February 2020
(This article belongs to the Section Antimicrobial Agents and Resistance)
Growing resistance to antibiotics is one of the biggest threats to human health. One of the possibilities to overcome this resistance is to use and develop alternative molecules such as antimicrobial peptides (AMPs). However, an increasing number of studies have shown that bacterial resistance to AMPs does exist. Since AMPs are immunity molecules, it is important to ensure that their potential therapeutic use is not harmful in the long term. Recently, several studies have focused on the adaptation of Gram-negative bacteria to subinhibitory concentrations of AMPs. Such concentrations are commonly found in vivo and in the environment. It is therefore necessary to understand how bacteria detect and respond to low concentrations of AMPs. This review focuses on recent findings regarding the impact of subinhibitory concentrations of AMPs on the modulation of virulence and resistance in Gram-negative bacteria. View Full-Text
Keywords: antimicrobial peptide; subinhibitory concentration; Gram-negative; virulence; resistance antimicrobial peptide; subinhibitory concentration; Gram-negative; virulence; resistance
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Duperthuy, M. Antimicrobial Peptides: Virulence and Resistance Modulation in Gram-Negative Bacteria. Microorganisms 2020, 8, 280.

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