Next Article in Journal
Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of Staphylococcus aureus
Previous Article in Journal
Modulation of Campylobacter jejuni Motility, Adhesion to Polystyrene Surfaces, and Invasion of INT407 Cells by Quorum-Sensing Inhibition
Previous Article in Special Issue
Role of Hfq in Genome Evolution: Instability of G-Quadruplex Sequences in E. coli
Review

Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes

Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Microorganisms 2020, 8(1), 105; https://doi.org/10.3390/microorganisms8010105
Received: 4 December 2019 / Revised: 7 January 2020 / Accepted: 9 January 2020 / Published: 11 January 2020
The segregation of newly replicated chromosomes in bacterial cells is a highly coordinated spatiotemporal process. In the majority of bacterial species, a tripartite ParAB-parS system, composed of an ATPase (ParA), a DNA-binding protein (ParB), and its target(s) parS sequence(s), facilitates the initial steps of chromosome partitioning. ParB nucleates around parS(s) located in the vicinity of newly replicated oriCs to form large nucleoprotein complexes, which are subsequently relocated by ParA to distal cellular compartments. In this review, we describe the role of ParB in various processes within bacterial cells, pointing out interspecies differences. We outline recent progress in understanding the ParB nucleoprotein complex formation and its role in DNA segregation, including ori positioning and anchoring, DNA condensation, and loading of the structural maintenance of chromosome (SMC) proteins. The auxiliary roles of ParBs in the control of chromosome replication initiation and cell division, as well as the regulation of gene expression, are discussed. Moreover, we catalog ParB interacting proteins. Overall, this work highlights how different bacterial species adapt the DNA partitioning ParAB-parS system to meet their specific requirements. View Full-Text
Keywords: ParB; segrosome; chromosome segregation; cell division; gene expression regulation; partitioning proteins ParB; segrosome; chromosome segregation; cell division; gene expression regulation; partitioning proteins
Show Figures

Figure 1

MDPI and ACS Style

Kawalek, A.; Wawrzyniak, P.; Bartosik, A.A.; Jagura-Burdzy, G. Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes. Microorganisms 2020, 8, 105. https://doi.org/10.3390/microorganisms8010105

AMA Style

Kawalek A, Wawrzyniak P, Bartosik AA, Jagura-Burdzy G. Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes. Microorganisms. 2020; 8(1):105. https://doi.org/10.3390/microorganisms8010105

Chicago/Turabian Style

Kawalek, Adam; Wawrzyniak, Pawel; Bartosik, Aneta A.; Jagura-Burdzy, Grazyna. 2020. "Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes" Microorganisms 8, no. 1: 105. https://doi.org/10.3390/microorganisms8010105

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop