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Open AccessArticle

Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes

1
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
2
Section of Endocrinology, Department of Medicine, Jesse Brown VA Medical Center, Chicago, IL 60612, USA
3
Sequencing Core, Research Resources Center, University of Illinois, Chicago, IL 60612, USA
4
Research Informatics Core, Research Resources Center, University of Illinois, Chicago, IL 60612, USA
5
Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL 60153, USA
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(9), 320; https://doi.org/10.3390/microorganisms7090320
Received: 20 July 2019 / Revised: 27 August 2019 / Accepted: 30 August 2019 / Published: 5 September 2019
(This article belongs to the Special Issue Gut Microbiota: Its Role in Diabetes and Obesity)
Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (n = 75). The main outcomes included fecal microbial community structure (16S rRNA), gut permeability biomarkers (ELISA), and short-chain fatty acids (SCFAs, metabolome analysis). These outcomes were compared between obese and non-obese men, after adjusting for age. The results showed that lipopolysaccharide-binding protein (LBP), the ratio of LBP to CD14 (LBP/CD14), and SCFAs (propionic, butyric, isovaleric) were higher in obese (n = 41, age 58 years, BMI 36 kg/m2) versus non-obese (n = 34, age 55 years, BMI 26 kg/m2) men. BMI correlated positively with LBP, LBP/CD14 (p < 0.05 for both) and SCFAs (propionic, butyric, isovaleric, p < 0.01 for all). In the regression analysis, LBP, LBP/CD14, propionic and butyric acids were independent determinants of BMI. The study showed for the first time that selected microbiota biomarkers (LBP, LBP/CD14, propionic and butyric acids) together with several other relevant risks explained 39%–47% of BMI variability, emphasizing that factors other than microbiota-related biomarkers could be important. Further research is needed to provide clinical and mechanistic insight into microbiota biomarkers and their utility for diagnostic and therapeutic purposes. View Full-Text
Keywords: gut microbiota; BMI; body mass index; CD14; cluster of differentiation 14 protein; EndoCab; endotoxin core antibody; LBP; lipopolysaccharide-binding protein; SCFA; short-chain fatty acids; zonulin; butyric; propionic; obesity; type 2 diabetes mellitus; African American men; cortisol gut microbiota; BMI; body mass index; CD14; cluster of differentiation 14 protein; EndoCab; endotoxin core antibody; LBP; lipopolysaccharide-binding protein; SCFA; short-chain fatty acids; zonulin; butyric; propionic; obesity; type 2 diabetes mellitus; African American men; cortisol
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Barengolts, E.; Green, S.J.; Chlipala, G.E.; Layden, B.T.; Eisenberg, Y.; Priyadarshini, M.; Dugas, L.R. Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes. Microorganisms 2019, 7, 320.

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