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Functional Genomics of Aspergillus oryzae: Strategies and Progress

Jiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In-vitro Diagnostic Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science & Technology Normal University, Nanchang 330013, China
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(4), 103;
Received: 27 February 2019 / Revised: 1 April 2019 / Accepted: 6 April 2019 / Published: 10 April 2019
(This article belongs to the Section Food Microbiology)
PDF [836 KB, uploaded 21 April 2019]


Aspergillus oryzae has been used for the production of traditional fermentation and has promising potential to produce primary and secondary metabolites. Due to the tough cell walls and high drug resistance of A. oryzae, functional genomic characterization studies are relatively limited. The exploitation of selection markers and genetic transformation methods are critical for improving A. oryzae fermentative strains. In this review, we describe the genome sequencing of various A. oryzae strains. Recently developed selection markers and transformation strategies are also described in detail, and the advantages and disadvantages of transformation methods are presented. Lastly, we introduce the recent progress on highlighted topics in A. oryzae functional genomics including conidiation, protein secretion and expression, and secondary metabolites, which will be beneficial for improving the application of A. oryzae to industrial production. View Full-Text
Keywords: Aspergillus oryzae; functional genomics; selection markers; transformation strategies Aspergillus oryzae; functional genomics; selection markers; transformation strategies

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He, B.; Tu, Y.; Jiang, C.; Zhang, Z.; Li, Y.; Zeng, B. Functional Genomics of Aspergillus oryzae: Strategies and Progress. Microorganisms 2019, 7, 103.

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