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Open AccessArticle

Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome

by Junwon Yang 1,2, Jonghyun Park 1,2, Sein Park 1,2, Inwoo Baek 2,3 and Jongsik Chun 1,2,3,*
1
Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Korea
2
Institute of Molecular Biology & Genetics, Seoul National University, Seoul 08826, Korea
3
School of Biological Sciences, Seoul National University, Seoul 08826, Korea
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(11), 480; https://doi.org/10.3390/microorganisms7110480
Received: 11 September 2019 / Revised: 17 October 2019 / Accepted: 21 October 2019 / Published: 23 October 2019
(This article belongs to the Section Gut Microbiota)
The gut microbiota modulates overall metabolism, the immune system and brain development of the host. The majority of mammalian gut microbiota consists of bacteria. Among various model animals, the mouse has been most widely used in pre-clinical biological experiments. The significant compositional differences in taxonomic profiles among different mouse strains due to gastrointestinal locations, genotypes and vendors have been well documented. However, details of such variations are yet to be elucidated. This study compiled and analyzed 16S rRNA gene-based taxonomic profiles of 554 healthy mouse samples from 14 different projects to construct a comprehensive database of the microbiome of a healthy mouse gastrointestinal tract. The database, named Murine Microbiome Database, should provide researchers with useful taxonomic information and better biological insight about how each taxon, such as genus and species, is associated with locations in the gastrointestinal tract, genotypes and vendors. The database is freely accessible over the Internet. View Full-Text
Keywords: database; metagenomics; mouse gut microbiome database; metagenomics; mouse gut microbiome
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Yang, J.; Park, J.; Park, S.; Baek, I.; Chun, J. Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome. Microorganisms 2019, 7, 480.

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