Next Article in Journal
Antimicrobial Resistance in Class 1 Integron-Positive Shiga Toxin-Producing Escherichia coli Isolated from Cattle, Pigs, Food and Farm Environment
Next Article in Special Issue
Leaky Gut, Leaky Brain?
Previous Article in Journal
Thermophilic Proteins as Versatile Scaffolds for Protein Engineering
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessArticle
Microorganisms 2018, 6(4), 98;

Gut Microbiota in Patients with Different Metabolic Statuses: Moscow Study

Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, bld. 16, 1st Leonova Street, Moscow 129226, Russia
Medical Research and Education Center, Lomonosov Moscow State University, 1 Leninskie Gory, Moscow 119991, Russia
Atlas Biomed Group, Tintagel House, 92 Albert Embankment, Lambeth, London SE1 7TP, UK
Author to whom correspondence should be addressed.
Received: 21 August 2018 / Revised: 17 September 2018 / Accepted: 18 September 2018 / Published: 25 September 2018
(This article belongs to the Special Issue Gut Microbiota Diversity Relates to Lifestyle)
Full-Text   |   PDF [1257 KB, uploaded 25 September 2018]   |  


The aim of this paper was to study gut microbiota composition in patients with different metabolic statuses. Methods: 92 participants aged 25–76 years (26 of whom were men), with confirmed absence of cardiovascular and other chronic diseases (but with the possible presence of cardiovascular risk factors) were included. Carotid ultrasound examinations, 16S rRNA sequencing of stool samples and diet assessments were performed. Statistical analysis was performed using R programming language, 3.1.0. Results: Enterotyping yielded two clusters differentiated by alpha-diversity. Intima-media thickness was higher in the cluster with lower diversity (adj. p < 0.001). Obesity was associated with higher Serratia (adj. p = 0.003) and Prevotella (adj. p < 0.0003) in relative abundance. Abdominal obesity was associated with higher abundance of Serratia (adj. p = 0.004) and Prevotella (adj. p = 0.0008) and lower levels of Oscillospira (adj. p = 0.0005). Glucose metabolism disturbances were associated with higher Blautia (adj. p = 0.0007) and Serratia (adj. p = 0.003) prevalence. Arterial hypertension was associated with high Blautia levels (adj. p = 0.002). The Blautia genus strongly correlated with low resistant starch consumption (adj. p = 0.007). A combination of high-fat diet and elevated Blautia levels was very common for diabetes mellitus type 2 patients (adj. p = 0.0001). Conclusion: The results show that there is a relationship between metabolic changes and higher representation of opportunistic pathogens and low diversity of gut microbiota even in apparently healthy participants. View Full-Text
Keywords: gut microbiota; metabolic status; glucose metabolism; cardiovascular risk factors; diet gut microbiota; metabolic status; glucose metabolism; cardiovascular risk factors; diet

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kashtanova, D.A.; Tkacheva, O.N.; Doudinskaya, E.N.; Strazhesko, I.D.; Kotovskaya, Y.V.; Popenko, A.S.; Tyakht, A.V.; Alexeev, D.G. Gut Microbiota in Patients with Different Metabolic Statuses: Moscow Study. Microorganisms 2018, 6, 98.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top