Next Article in Journal / Special Issue
Novel Effector Protein EspY3 of Type III Secretion System from Enterohemorrhagic Escherichia coli Is Localized in Actin Pedestals
Previous Article in Journal
Transfer RNA Modification Enzymes from Thermophiles and Their Modified Nucleosides in tRNA
Previous Article in Special Issue
Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessReview
Microorganisms 2018, 6(4), 111;

Shiga Toxin-Producing Escherichia coli Infections during Pregnancy

Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires 1121, Argentina
Laboratorio de Hematología, Hospital Universitario Austral, Pilar, Buenos Aires 1629, Argentina
CEFYBO-CONICET, Universidad de Buenos Aires, Buenos Aires 1121, Argentina
Authors to whom correspondence should be addressed.
Received: 26 September 2018 / Revised: 17 October 2018 / Accepted: 19 October 2018 / Published: 23 October 2018
(This article belongs to the Special Issue Pathogenesis of Enterohaemorrhagic Escherichia coli)
Full-Text   |   PDF [511 KB, uploaded 23 October 2018]   |  


Gastrointestinal infection with Shiga toxin-producing Escherichia coli (STEC) causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS), characterized by hemolytic anemia, thrombocytopenia and acute renal failure. The main virulence factor of STEC is Shiga toxin (Stx), which is responsible for HUS development. STEC can produce Stx type 1 and/or 2 (Stx1, Stx2) and their variants, Stx2 being more frequently associated with severe cases of HUS. This pathology occurs in 5–15% of cases with STEC infection when Stx gain access to the bloodstream and causes damage in the target organs such as the kidney and brain. STEC infections affect mainly young children, although the large HUS outbreak with a new Stx2-producing STEC O104:H4 in Europe in 2011 involved more adults than children, and women were over-represented. Maternal infections during pregnancy are associated with adverse pregnancy outcomes. Studies in rats showed that Stx2 binds to the utero-placental unit and causes adverse pregnancy outcomes. In this article, we provide a brief overview of Stx2 action on placental tissues and discuss whether they might cause pregnancy loss or preterm birth. View Full-Text
Keywords: STEC infections; pregnancy; Shiga toxin; prevention STEC infections; pregnancy; Shiga toxin; prevention

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Sacerdoti, F.; Scalise, M.L.; Burdet, J.; Amaral, M.M.; Franchi, A.M.; Ibarra, C. Shiga Toxin-Producing Escherichia coli Infections during Pregnancy. Microorganisms 2018, 6, 111.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top