Next Article in Journal
Purine Acquisition and Synthesis by Human Fungal Pathogens
Previous Article in Journal
Changes in Microbial (Bacteria and Archaea) Plankton Community Structure after Artificial Dispersal in Grazer-Free Microcosms
Previous Article in Special Issue
Immune Response to Coccidioidomycosis and the Development of a Vaccine

Interaction of Candida Species with the Skin

Department of Molecular Biotechnology, Fraunhofer Institute for Interfacial Engineering and Biotechnology, 70569 Stuttgart, Germany
Institute of Interfacial Process Engineering and Plasma Technology, University of Stuttgart, 70569 Stuttgart, Germany
Author to whom correspondence should be addressed.
Academic Editor: Floyd L. Wormley
Microorganisms 2017, 5(2), 32;
Received: 4 April 2017 / Revised: 30 May 2017 / Accepted: 2 June 2017 / Published: 7 June 2017
(This article belongs to the Special Issue Fungal Pathogenesis and Immune Defense)
The human skin is commonly colonized by diverse fungal species. Some Candida species, especially C. albicans, do not only reside on the skin surface as commensals, but also cause infections by growing into the colonized tissue. However, defense mechanisms at the skin barrier level are very efficient, involving residential non-immune and immune cells as well as immune cells specifically recruited to the site of infection. Therefore, the skin is an effective barrier against fungal infection. While most studies about commensal and pathogenic interaction of Candida species with host epithelia focus on the interaction with mucosal surfaces such as the vaginal and gastrointestinal epithelia, less is known about the mechanisms underlying Candida interaction with the skin. In this review, we focus on the ecology and molecular pathogenesis of Candida species on the skin and give an overview of defense mechanisms against C. albicans in this context. We also discuss new research avenues in dermal infection, including the involvement of neurons, fibroblasts, and commensal bacteria in both mouse and human model systems. View Full-Text
Keywords: Candida; skin infection; 3D-tissue models; innate immunity; fibroblasts Candida; skin infection; 3D-tissue models; innate immunity; fibroblasts
Show Figures

Figure 1

MDPI and ACS Style

Kühbacher, A.; Burger-Kentischer, A.; Rupp, S. Interaction of Candida Species with the Skin. Microorganisms 2017, 5, 32.

AMA Style

Kühbacher A, Burger-Kentischer A, Rupp S. Interaction of Candida Species with the Skin. Microorganisms. 2017; 5(2):32.

Chicago/Turabian Style

Kühbacher, Andreas, Anke Burger-Kentischer, and Steffen Rupp. 2017. "Interaction of Candida Species with the Skin" Microorganisms 5, no. 2: 32.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop