Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors
Abstract
:1. Introduction
2. Lead Discovery Strategies
2.1. Epidemiological/Ethnopharmacological Approach
2.2. Target-Based Virtual Screening
2.3. Ligand-Based Virtual Screening
2.4. Pharmacophore-Based Design
3. Plant Phenolics as Antichlamydial Agents
3.1. Oxidative Stress
3.2. Mitogen-Activated Protein Kinases
3.3. Intracellular Calcium Levels
4. Models of Persistent Infection
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Target | C. pneumoniae | Luteolin | References |
---|---|---|---|
ROS | + | − | [30,33,34] |
NF-κB | + | − | [31,39] |
MAP kinases | + | +/− | [32,36] |
PI3 kinase | + | − | [53,54] |
Cytosolic Ca2+ | + | +/− | [35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52] |
Bcl-2 proteins | − | +/− | [56,58] |
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Hanski, L.; Vuorela, P. Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors. Microorganisms 2016, 4, 43. https://doi.org/10.3390/microorganisms4040043
Hanski L, Vuorela P. Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors. Microorganisms. 2016; 4(4):43. https://doi.org/10.3390/microorganisms4040043
Chicago/Turabian StyleHanski, Leena, and Pia Vuorela. 2016. "Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors" Microorganisms 4, no. 4: 43. https://doi.org/10.3390/microorganisms4040043