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Volume 12
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10.3390/microorganisms12071405
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Review

Multiple Functions of Hepatitis E Virus ORF3

by
Fengyuan Jiao
1,†,
Yu Zhao
2,†,
Gengxu Zhou
1,
Chi Meng
1,
Lingjie Wang
1,
Shengping Wu
1,
Jixiang Li
1,
Liting Cao
1,
Bo Zhou
3,
Yichen Luo
1,* and
Hanwei Jiao
1,*
1
The College of Veterinary Medicine, Southwest University, Chongqing 402460, China
2
Ministry of Agriculture and Rural Affairs Key Laboratory of Crop Genitic Resources and Germplasm Innovation in Karst Region, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Science, Guiyang 550005, China
3
Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Yujinxiang Street 573, Changchun 130102, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2024, 12(7), 1405; https://doi.org/10.3390/microorganisms12071405
Submission received: 16 June 2024 / Revised: 5 July 2024 / Accepted: 8 July 2024 / Published: 11 July 2024
(This article belongs to the Section Virology)
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Abstract

Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The pathogen, HEV, has three Open Reading Frames (ORFs) ORF1, ORF2, and ORF3, each of which has a different function. Most of the current research is focused on ORF1 and ORF2, while the research on ORF3 is still relatively small. To provide more ideas for the study of HEV pathogenesis and the prevention and treatment of HE, this paper reviews the effects of ORF3 on the ERK pathway, growth factors, immune response, and virus release.
Keywords: HE; HEV; ORF3 HE; HEV; ORF3

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MDPI and ACS Style

Jiao, F.; Zhao, Y.; Zhou, G.; Meng, C.; Wang, L.; Wu, S.; Li, J.; Cao, L.; Zhou, B.; Luo, Y.; et al. Multiple Functions of Hepatitis E Virus ORF3. Microorganisms 2024, 12, 1405. https://doi.org/10.3390/microorganisms12071405

AMA Style

Jiao F, Zhao Y, Zhou G, Meng C, Wang L, Wu S, Li J, Cao L, Zhou B, Luo Y, et al. Multiple Functions of Hepatitis E Virus ORF3. Microorganisms. 2024; 12(7):1405. https://doi.org/10.3390/microorganisms12071405

Chicago/Turabian Style

Jiao, Fengyuan, Yu Zhao, Gengxu Zhou, Chi Meng, Lingjie Wang, Shengping Wu, Jixiang Li, Liting Cao, Bo Zhou, Yichen Luo, and et al. 2024. "Multiple Functions of Hepatitis E Virus ORF3" Microorganisms 12, no. 7: 1405. https://doi.org/10.3390/microorganisms12071405

APA Style

Jiao, F., Zhao, Y., Zhou, G., Meng, C., Wang, L., Wu, S., Li, J., Cao, L., Zhou, B., Luo, Y., & Jiao, H. (2024). Multiple Functions of Hepatitis E Virus ORF3. Microorganisms, 12(7), 1405. https://doi.org/10.3390/microorganisms12071405

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