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Microorganisms
Volume 11
Issue 4
10.3390/microorganisms11040928
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Article

Clinical Features and Outcomes of Persistent Candidemia Caused by Candida albicans versus Non-albicans Candida Species: A Focus on Antifungal Resistance and Follow-Up Blood Cultures

by
Shiori Kitaya
1,2,*,†,
Hajime Kanamori
1,*,†,
Yukio Katori
2 and
Koichi Tokuda
1
1
Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan
2
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2023, 11(4), 928; https://doi.org/10.3390/microorganisms11040928
Submission received: 11 March 2023 / Revised: 24 March 2023 / Accepted: 30 March 2023 / Published: 3 April 2023
(This article belongs to the Special Issue Candida Species Virulence Factors and Their Pathogenicity)
Review Reports Versions Notes

Abstract

The clinical distinctions among variations in Candida species, antifungal resistance (AFR), and clearance status of hospital-acquired persistent candidemia (HA-PC) remain uncertain. This secondary analysis of a retrospective cohort study aimed to assess the differences in HA-PC based on different Candida species, AFR, and persistent candidemia (PC) clearance status. A retrospective review was conducted using medical records from Tohoku University Hospital of patients for whom blood cultures were performed between January 2012 and December 2021. PC cases were categorized into groups based on Candida species, azole, or echinocandin resistance, as well as PC-clearance status, and the respective characteristics were analyzed. The HA-PC non-clearance group had a tendency toward higher 30–90-day and 90-day mortality rates compared to the HA-PC-clearance group in both the susceptible and resistant strain groups, with the former group demonstrating a statistically significant difference (odds ratio = 19, p = 0.028). The high mortality rate observed in the Candida non-albicans and resistant strain groups necessitates a more meticulous therapeutic management approach for PC. Follow-up blood cultures and confirmation of PC clearance are useful for improving the survival rates of both the HA-PC-susceptible and -resistant strain groups.
Keywords: hospital-acquired persistent candidemia; antifungal resistance; clearance of persistent candidemia hospital-acquired persistent candidemia; antifungal resistance; clearance of persistent candidemia

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MDPI and ACS Style

Kitaya, S.; Kanamori, H.; Katori, Y.; Tokuda, K. Clinical Features and Outcomes of Persistent Candidemia Caused by Candida albicans versus Non-albicans Candida Species: A Focus on Antifungal Resistance and Follow-Up Blood Cultures. Microorganisms 2023, 11, 928. https://doi.org/10.3390/microorganisms11040928

AMA Style

Kitaya S, Kanamori H, Katori Y, Tokuda K. Clinical Features and Outcomes of Persistent Candidemia Caused by Candida albicans versus Non-albicans Candida Species: A Focus on Antifungal Resistance and Follow-Up Blood Cultures. Microorganisms. 2023; 11(4):928. https://doi.org/10.3390/microorganisms11040928

Chicago/Turabian Style

Kitaya, Shiori, Hajime Kanamori, Yukio Katori, and Koichi Tokuda. 2023. "Clinical Features and Outcomes of Persistent Candidemia Caused by Candida albicans versus Non-albicans Candida Species: A Focus on Antifungal Resistance and Follow-Up Blood Cultures" Microorganisms 11, no. 4: 928. https://doi.org/10.3390/microorganisms11040928

APA Style

Kitaya, S., Kanamori, H., Katori, Y., & Tokuda, K. (2023). Clinical Features and Outcomes of Persistent Candidemia Caused by Candida albicans versus Non-albicans Candida Species: A Focus on Antifungal Resistance and Follow-Up Blood Cultures. Microorganisms, 11(4), 928. https://doi.org/10.3390/microorganisms11040928

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