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Microorganisms
Volume 10
Issue 7
10.3390/microorganisms10071294
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Review

The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs

by
Sen Zeng
1,2,†,
Yuwan Li
1,2,†,
Wenhui Zhu
1,2,†,
Zipeng Luo
1,2,
Keke Wu
1,3,
Xiaowen Li
1,3,
Yiqi Fang
1,2,
Yuwei Qin
1,2,
Wenxian Chen
1,3,
Zhaoyao Li
1,3,
Linke Zou
1,2,
Xiaodi Liu
1,2,
Lin Yi
1,2,3,* and
Shuangqi Fan
1,2,3,*
1
College of Veterinary Medicine, South China Agricultural University, No. 483 Wushan Road, Tianhe District, Guangzhou 510642, China
2
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China
3
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2022, 10(7), 1294; https://doi.org/10.3390/microorganisms10071294
Submission received: 31 May 2022 / Revised: 22 June 2022 / Accepted: 24 June 2022 / Published: 26 June 2022
(This article belongs to the Special Issue Recent Advances in Antivirals for Emerging Viruses 2.0)
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Abstract

Coronaviruses, mainly including severe acute respiratory syndrome virus, severe acute respiratory syndrome coronavirus 2, Middle East respiratory syndrome virus, human coronavirus OC43, chicken infectious bronchitis virus, porcine infectious gastroenteritis virus, porcine epidemic diarrhea virus, and murine hepatitis virus, can cause severe diseases in humans and livestock. The severe acute respiratory syndrome coronavirus 2 is infecting millions of human beings with high morbidity and mortality worldwide, and the multiplicity of swine epidemic diarrhea coronavirus in swine suggests that coronaviruses seriously jeopardize the safety of public health and that therapeutic intervention is urgently needed. Currently, the most effective methods of prevention and control for coronaviruses are vaccine immunization and pharmacotherapy. However, the emergence of mutated viruses reduces the effectiveness of vaccines. In addition, vaccine developments often lag behind, making it difficult to put them into use early in the outbreak. Therefore, it is meaningful to screen safe, cheap, and broad-spectrum antiviral agents for coronaviruses. This review systematically summarizes the mechanisms and state of anti-human and porcine coronavirus drugs, in order to provide theoretical support for the development of anti-coronavirus drugs and other antivirals.
Keywords: antiviral drugs; coronaviruses; SARS-CoV-2; PEDV; TCM antiviral drugs; coronaviruses; SARS-CoV-2; PEDV; TCM

Share and Cite

MDPI and ACS Style

Zeng, S.; Li, Y.; Zhu, W.; Luo, Z.; Wu, K.; Li, X.; Fang, Y.; Qin, Y.; Chen, W.; Li, Z.; et al. The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs. Microorganisms 2022, 10, 1294. https://doi.org/10.3390/microorganisms10071294

AMA Style

Zeng S, Li Y, Zhu W, Luo Z, Wu K, Li X, Fang Y, Qin Y, Chen W, Li Z, et al. The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs. Microorganisms. 2022; 10(7):1294. https://doi.org/10.3390/microorganisms10071294

Chicago/Turabian Style

Zeng, Sen, Yuwan Li, Wenhui Zhu, Zipeng Luo, Keke Wu, Xiaowen Li, Yiqi Fang, Yuwei Qin, Wenxian Chen, Zhaoyao Li, and et al. 2022. "The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs" Microorganisms 10, no. 7: 1294. https://doi.org/10.3390/microorganisms10071294

APA Style

Zeng, S., Li, Y., Zhu, W., Luo, Z., Wu, K., Li, X., Fang, Y., Qin, Y., Chen, W., Li, Z., Zou, L., Liu, X., Yi, L., & Fan, S. (2022). The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs. Microorganisms, 10(7), 1294. https://doi.org/10.3390/microorganisms10071294

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