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Article

Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol

Chemical Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Wiltshire SP4 0JQ, UK
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Author to whom correspondence should be addressed.
Pathogens 2020, 9(9), 680; https://doi.org/10.3390/pathogens9090680
Received: 30 July 2020 / Revised: 13 August 2020 / Accepted: 18 August 2020 / Published: 21 August 2020
(This article belongs to the Special Issue Hemorrhagic Fever Viruses)
Knowledge of the survival and stability of a pathogen is important for understanding its risk, reducing its transmission, and establishing control measures. Lassa virus is endemic in West Africa, causes severe disease, and is an emerging pathogen of concern. Our study examined the survival of Lassa virus in blood and tissue culture media at two different temperatures. The stability of Lassa virus held within a small particle aerosol was also measured. In liquids, Lassa virus was found to decay more quickly at 30 °C compared to room temperature. Sealed samples protected from environmental desiccation were more stable than samples open to the environment. In a small particle aerosol, the decay rate of Lassa virus was determined at 2.69% per minute. This information can contribute to risk assessments and inform mitigation strategies in the event of an outbreak of Lassa virus. View Full-Text
Keywords: Lassa virus; survival; aerosol; blood; tissue culture media; stability Lassa virus; survival; aerosol; blood; tissue culture media; stability
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MDPI and ACS Style

Smither, S.J.; Eastaugh, L.S.; Findlay, J.S.; O’Brien, L.M.; Lever, M.S. Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol. Pathogens 2020, 9, 680. https://doi.org/10.3390/pathogens9090680

AMA Style

Smither SJ, Eastaugh LS, Findlay JS, O’Brien LM, Lever MS. Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol. Pathogens. 2020; 9(9):680. https://doi.org/10.3390/pathogens9090680

Chicago/Turabian Style

Smither, Sophie J.; Eastaugh, Lin S.; Findlay, James S.; O’Brien, Lyn M.; Lever, Mark S. 2020. "Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol" Pathogens 9, no. 9: 680. https://doi.org/10.3390/pathogens9090680

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