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Article

Inhibitory Properties of Aldehydes and Related Compounds against Phytophthora infestans—Identification of a New Lead

1
Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, Ireland
2
School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland
3
School of Biological, Earth and Environmental Sciences, University College Cork, T12 K8AF Cork, Ireland
*
Authors to whom correspondence should be addressed.
Pathogens 2020, 9(7), 542; https://doi.org/10.3390/pathogens9070542
Received: 5 June 2020 / Revised: 1 July 2020 / Accepted: 3 July 2020 / Published: 7 July 2020
(This article belongs to the Special Issue Biology and Pathology of Phytophthora infestans)
The pathogen Phytophthora infestans is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current strategies for crop treatment are inadequate with the emergence of resistant strains and problematic toxicity. Natural products such as cinnamaldehyde have been reported to have fungicidal properties and are the seed for many new discovery research programmes. We report a probe of the cinnamaldehyde framework to investigate the aldehyde subunit and its role in a subset of aromatic aldehydes in order to identify new lead compounds to act against P. infestans. An ellipticine derivative which incorporates an aldehyde (9-formyl-6-methyl ellipticine, 34) has been identified with exceptional activity versus P. infestans with limited toxicity and potential for use as a fungicide. View Full-Text
Keywords: Phytophthora infestans; cinnamaldehyde; thiosemicarbazone; ellipticine; fungicide Phytophthora infestans; cinnamaldehyde; thiosemicarbazone; ellipticine; fungicide
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MDPI and ACS Style

Mackrill, J.J.; Kehoe, R.A.; Zheng, L.; McKee, M.L.; O’Sullivan, E.C.; Prestwich, B.M.D.; McCarthy, F.O. Inhibitory Properties of Aldehydes and Related Compounds against Phytophthora infestans—Identification of a New Lead. Pathogens 2020, 9, 542. https://doi.org/10.3390/pathogens9070542

AMA Style

Mackrill JJ, Kehoe RA, Zheng L, McKee ML, O’Sullivan EC, Prestwich BMD, McCarthy FO. Inhibitory Properties of Aldehydes and Related Compounds against Phytophthora infestans—Identification of a New Lead. Pathogens. 2020; 9(7):542. https://doi.org/10.3390/pathogens9070542

Chicago/Turabian Style

Mackrill, John J., Roberta A. Kehoe, Limian Zheng, Mary L. McKee, Elaine C. O’Sullivan, Barbara M.D. Prestwich, and Florence O. McCarthy 2020. "Inhibitory Properties of Aldehydes and Related Compounds against Phytophthora infestans—Identification of a New Lead" Pathogens 9, no. 7: 542. https://doi.org/10.3390/pathogens9070542

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