Gut Microbiome in Psoriasis: An Updated Review
1
Department of Dermatology, Medical University of Warsaw, 02-091 Warsaw, Poland
2
Student Research Committee, Department of Dermatology, Medical University of Warsaw, 02-091 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(6), 463; https://doi.org/10.3390/pathogens9060463
Received: 8 May 2020
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Revised: 29 May 2020
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Accepted: 8 June 2020
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Published: 12 June 2020
(1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut–skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The objective of this study was to synthesize current data on the gut microbial composition in psoriasis. (2) Methods: We conducted a systematic review of studies investigating intestinal microbiome in psoriasis, using the PRISMA checklist. We searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2000–2020). (3) Results: All of the 10 retrieved studies reported alterations in the gut microbiome in patients with psoriasis. Eight studies assessed alpha- and beta-diversity. Four of them reported a lack of change in alpha-diversity, but all confirmed significant changes in beta-diversity. At the phylum-level, at least two or more studies reported a lower relative abundance of Bacteroidetes, and higher Firmicutes in psoriasis patients versus healthy controls. (4) Conclusions: There is a significant association between alterations in gut microbial composition and psoriasis; however, there is high heterogeneity between studies. More unified methodological standards in large-scale studies are needed to understand microbiota’s contribution to psoriasis pathogenesis and its modulation as a potential therapeutic strategy.
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Keywords:
microbiome; psoriasis; gut-skin axis; gut barrier; systematic review
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MDPI and ACS Style
Sikora, M.; Stec, A.; Chrabaszcz, M.; Knot, A.; Waskiel-Burnat, A.; Rakowska, A.; Olszewska, M.; Rudnicka, L. Gut Microbiome in Psoriasis: An Updated Review. Pathogens 2020, 9, 463. https://doi.org/10.3390/pathogens9060463
AMA Style
Sikora M, Stec A, Chrabaszcz M, Knot A, Waskiel-Burnat A, Rakowska A, Olszewska M, Rudnicka L. Gut Microbiome in Psoriasis: An Updated Review. Pathogens. 2020; 9(6):463. https://doi.org/10.3390/pathogens9060463
Chicago/Turabian StyleSikora, Mariusz, Albert Stec, Magdalena Chrabaszcz, Aleksandra Knot, Anna Waskiel-Burnat, Adriana Rakowska, Malgorzata Olszewska, and Lidia Rudnicka. 2020. "Gut Microbiome in Psoriasis: An Updated Review" Pathogens 9, no. 6: 463. https://doi.org/10.3390/pathogens9060463
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